- Sydney, New South Wales, Australia
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Kaposi’s sarcoma (KS) is a malignant vascular tumor, caused by the human herpesvirus 8. It is one of the commonest tumors in human immunodeficiency virus (HIV) patients and not uncommonly the first manifestation of acquired... more
Kaposi’s sarcoma (KS) is a malignant vascular tumor, caused by the human herpesvirus 8. It is one of the commonest tumors in human immunodeficiency virus (HIV) patients and not uncommonly the first manifestation of acquired immunodeficiency syndrome (AIDS).Case. We present a case of an isolated bulbar conjunctival KS on a 43-year-old HIV positive male, with no other lesions. Excision and cryotherapy were performed, and the patient remains free of lesions to date.Conclusion. Isolated bulbar conjunctival KP is an unusual site for its initial presentation and must be kept in mind in HIV positive patients.
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Ophthalmology, Treatment Outcome, Porphyrins, Medicine, Photodynamic Therapy, and 15 moreVisual acuity, Safety, Prospective studies, Humans, Female, Male, American, Clinical Sciences, Aged, Middle Aged, Optometry and Ophthalmology, Photochemotherapy, Public health systems and services research, Retinal Diseases, and Choroidal Neovascularization Industry
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Patients with diabetic macular edema (DME) are at high risk of vascular complications, including stroke and myocardial infarction (MI). Concerns have been raised that intravitreal dosing of vascular endothelial growth factor inhibitors in... more
Patients with diabetic macular edema (DME) are at high risk of vascular complications, including stroke and myocardial infarction (MI). Concerns have been raised that intravitreal dosing of vascular endothelial growth factor inhibitors in DME could be associated with an increase in cardiovascular and cerebrovascular adverse events. To evaluate the cardiovascular and cerebrovascular safety of ranibizumab, 0.5 mg and 0.3 mg, compared with sham with and without laser in DME. Patient-level data from 6 randomized, double-masked, sham- and laser-controlled clinical trials. Company-sponsored (Genentech or Novartis) studies in DME completed as of December 31, 2013. Pairwise comparisons (ranibizumab, 0.5 mg, vs sham and laser; ranibizumab, 0.3 mg, vs sham) were performed using Cox proportional hazard regression (hazard ratios, 95% CIs) and rates per 100 person-years. Data analysis was conducted from June 1 to July 15, 2015. Standardized Medical Dictionary for Regulatory Activities queries an...
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Research Interests:
British, Treatment Outcome, Medicine, Macular Degeneration, Humans, and 15 moreFemale, Male, Age related macular degeneration, Clinical Sciences, Aged, Middle Aged, Optometry and Ophthalmology, Public health systems and services research, Retrospective Studies, Side Effect, Recombinant Proteins, Vascular Permeability, Interferon Alpha, Choroid, and Heart arrest
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... 123 Paul E. BEAUMONT* Iney, NSW 2006, Australia The Eye and Vision Research Institute, Sydney, NSW 2001, Australia Received June 1979 Revised July ... x111 (111)= JAN's sugar level bt (at) ) xull (2) = JAN's... more
... 123 Paul E. BEAUMONT* Iney, NSW 2006, Australia The Eye and Vision Research Institute, Sydney, NSW 2001, Australia Received June 1979 Revised July ... x111 (111)= JAN's sugar level bt (at) ) xull (2) = JAN's visual acuity bt (at) under ocular X 21 (X121) = JON's sugar level ...
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To quantify and categorize the lesions of neovascular age-related macular degeneration on the basis of fluorescein angiographic morphology. We retrospectively reviewed 3580 consecutive cases of neovascular age-related macular... more
To quantify and categorize the lesions of neovascular age-related macular degeneration on the basis of fluorescein angiographic morphology. We retrospectively reviewed 3580 consecutive cases of neovascular age-related macular degeneration. The lesions were graded in terms of the location, size, and composition and categorized according to the lesion components. A comprehensive schema for lesion description and categorization is presented. There were 2642 subfoveal (73.8%), 658 juxtafoveal (18.4%), and 276 extrafoveal (7.7%) lesions. After disciform lesions were excluded, 1337 subfoveal (72.3%), 580 juxtafoveal (88.1%), and 242 extrafoveal lesions (87.7%) consisted of at least 50% choroidal neovascularization, most of which included a classic or an occult component but not both. Subfoveal lesions (mean size, 2.82 Macular Photocoagulation Study disc areas) were significantly larger than juxtafoveal (mean size, 0.89 Macular Photocoagulation Study disc areas) or extrafoveal lesions (mea...
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A 37-year-old woman presented with flashes in her left eye and bilateral visual distortion. Fundal examination revealed a reticular 'fishnet' pattern of retinal pigmentation in both eyes consistent with reticular dystrophy of the... more
A 37-year-old woman presented with flashes in her left eye and bilateral visual distortion. Fundal examination revealed a reticular 'fishnet' pattern of retinal pigmentation in both eyes consistent with reticular dystrophy of the retinal pigment epithelium. In the left eye there was a small haemorrhage and a shallow serous macular detachment. Fluorescein angiography demonstrated subfoveal choroidal neovascularization. Indocyanine green angiography (ICG) revealed more extensive involvement than fluorescein angiography, with small areas of intense hyperfluorescence amongst reticular areas of hypofluorescence. These changes, as interpreted in light of the known histopathological localization of ICG, are consistent with varying stages of dysfunction of the retinal pigment epithelium in this disease.
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To investigate the association of cup-to-disc ratio (CDR), intraocular pressure (IOP), and primary open-angle glaucoma (POAG) with the site of retinal venous occlusion (RVO) and optic nerve head swelling (ONHS). Prospective observational... more
To investigate the association of cup-to-disc ratio (CDR), intraocular pressure (IOP), and primary open-angle glaucoma (POAG) with the site of retinal venous occlusion (RVO) and optic nerve head swelling (ONHS). Prospective observational case series. Four hundred fifty consecutive cases from a single tertiary referral center. Fundus photography of the retinopathy, 30 degrees stereo photography of the optic disc, and Goldmann applanation tonometry were the main parameters studied. The diagnosis of POAG was obtained from the referring ophthalmologist. The main outcome measures were the CDR, measured vertically through the center of the optic disc, and the site of RVO, identified as an arteriovenous (AV) crossing, optic cup, or optic nerve. Retinal venous occlusions occurring within the optic nerve were subdivided on the basis of the presence or absence of ONHS. There were poor correlations between CDR and IOP (r = 0.18; P = 0.000209) and CDR and age (r = 0.21; P = 0.000012). There wer...
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Archives of Ophthalmology, a monthly professional medical journal published by the American Medical Association, publishes peer-reviewed, original articles on all aspects of ophthalmology.
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Depression, Quality of life, Physical Activity, Linear models, Visual acuity, and 15 moreMacular Degeneration, Activities of Daily Living, Humans, Female, Male, Temporal Lobe Epilepsy, STEM (short form), Clinical Sciences, Aged, Questionnaires, Optometry and Ophthalmology, Social Relationship, Depressive Symptoms, Mesial Temporal Sclerosis, and Case Control Studies
Archives of Ophthalmology, a monthly professional medical journal published by the American Medical Association, publishes peer-reviewed, original articles on all aspects of ophthalmology.
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Australia, Regulation, Porphyrins, Photodynamic Therapy, Macular Degeneration, and 9 moreTherapeutic drug monitoring, Humans, Clinical, Incidence, Clinical Sciences, Optometry and Ophthalmology, Photochemotherapy, Public health systems and services research, and Indian Journal of Clinical and Experimental Ophthalmology
A 60-year-old Asian man presented with left rubeotic glau-coma secondary to a central retinal vein occlusion. He was successfully treated with laser diode cyclophotocoagulation of the ciliary body. Nine months later he developed right... more
A 60-year-old Asian man presented with left rubeotic glau-coma secondary to a central retinal vein occlusion. He was successfully treated with laser diode cyclophotocoagulation of the ciliary body. Nine months later he developed right progressive visual loss, headache, corneal ...