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Structure and Function of Influenza Virus Ribonucleoprotein

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Virus Protein and Nucleoprotein Complexes

Part of the book series: Subcellular Biochemistry ((SCBI,volume 88))

Abstract

Influenza is a negative-sense single-stranded RNA virus with segmented genome. Each segment is encapsidated by a ribonucleoprotein (RNP) complex composed of RNA-dependent RNA polymerase (RdRP) and multiple copies of nucleoprotein (NP). The RNP complex plays a crucial role in viral life cycle, supporting and regulating transcription and replication of viral genome in infected cells. The structural characterization of RdRP and RNP in recent years has shed light on its functions and mechanism of action. In this review, we summarize current understanding on the structure of RNP complex, as well as the structure of each subunit. Crucial functions of RNP are also discussed.

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Authors and Affiliations

  1. Centre for Protein Science and Crystallography, School of Life Sciences, The Chinese University of Hong Kong, Shatin, N.T, Hong Kong, China

    Chun-Yeung Lo, Yun-Sang Tang & Pang-Chui Shaw

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  1. Chun-Yeung Lo
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  2. Yun-Sang Tang
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  3. Pang-Chui Shaw
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Correspondence to Pang-Chui Shaw .

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Editors and Affiliations

  1. Institute of Zoology, University of Mainz, Mainz, Germany

    J. Robin Harris

  2. MRC-University of Glasgow Centre for Virus Research, Glasgow, UK

    David Bhella

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Lo, CY., Tang, YS., Shaw, PC. (2018). Structure and Function of Influenza Virus Ribonucleoprotein. In: Harris, J., Bhella, D. (eds) Virus Protein and Nucleoprotein Complexes. Subcellular Biochemistry, vol 88. Springer, Singapore. https://doi.org/10.1007/978-981-10-8456-0_5

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