Abstract
Beyond established roles in collagen biosynthesis, hypoxic signaling and fatty acid metabolism, recent reports have now revealed roles for human 2-oxoglutarate-dependent oxygenases in histone and nucleic acid demethylation and in signaling protein hydroxylation. The emerging role of these oxygenases in enabling a multiplicity of histone modifications has some analogy with their role in enabling structural diversity in secondary metabolism.
Publication types
- Research Support, Non-U.S. Gov't
MeSH terms
- Animals
- Catalysis
- Histones / chemistry
- Histones / physiology
- Humans
- Hydroxylation
- Ketoglutaric Acids / metabolism*
- Methylation
- Models, Molecular
- Nucleic Acids / chemical synthesis
- Nucleic Acids / chemistry
- Oxidation-Reduction
- Oxygenases / chemistry*
- Oxygenases / physiology*
- Proteins / chemistry
- Proteins / physiology
- Signal Transduction / physiology
- Stereoisomerism
Substances
- Histones
- Ketoglutaric Acids
- Nucleic Acids
- Proteins
- Oxygenases