Genetic analysis and antigenic characterization of swine origin influenza viruses isolated from humans in the United States, 1990-2010

Bo Shu; Rebecca Garten; Shannon Emery; Amanda Balish; Lynn Cooper; Wendy Sessions; Varough Deyde; Catherine Smith; LaShondra Berman; Alexander Klimov; Stephen Lindstrom; Xiyan Xu

doi:10.1016/j.virol.2011.10.016

Genetic analysis and antigenic characterization of swine origin influenza viruses isolated from humans in the United States, 1990-2010

Virology. 2012 Jan 5;422(1):151-60. doi: 10.1016/j.virol.2011.10.016. Epub 2011 Nov 10.

Authors

Bo Shu¹, Rebecca Garten, Shannon Emery, Amanda Balish, Lynn Cooper, Wendy Sessions, Varough Deyde, Catherine Smith, LaShondra Berman, Alexander Klimov, Stephen Lindstrom, Xiyan Xu

Affiliation

¹ Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.

PMID: 22078166
DOI: 10.1016/j.virol.2011.10.016

Abstract

Swine influenza viruses (SIV) have been recognized as important pathogens for pigs and occasional human infections with swine origin influenza viruses (SOIV) have been reported. Between 1990 and 2010, a total of twenty seven human cases of SOIV infections have been identified in the United States. Six viruses isolated from 1990 to 1995 were recognized as classical SOIV (cSOIV) A(H1N1). After 1998, twenty-one SOIV recovered from human cases were characterized as triple reassortant (tr_SOIV) inheriting genes from classical swine, avian and human influenza viruses. Of those twenty-one tr_SOIV, thirteen were of A(H1N1), one of A(H1N2), and seven of A(H3N2) subtype. SOIV characterized were antigenically and genetically closely related to the subtypes of influenza viruses circulating in pigs but distinct from contemporary influenza viruses circulating in humans. The diversity of subtypes and genetic lineages in SOIV cases highlights the importance of continued surveillance at the animal-human interface.

MeSH terms

Antigens, Viral
Base Sequence
Genetic Variation
Genome, Viral
Hemagglutinin Glycoproteins, Influenza Virus / genetics
Hemagglutinin Glycoproteins, Influenza Virus / immunology
Humans
Influenza A Virus, H1N1 Subtype* / classification
Influenza A Virus, H1N1 Subtype* / genetics
Influenza A Virus, H1N1 Subtype* / immunology
Influenza A Virus, H1N1 Subtype* / isolation & purification
Influenza A Virus, H1N2 Subtype* / classification
Influenza A Virus, H1N2 Subtype* / genetics
Influenza A Virus, H1N2 Subtype* / immunology
Influenza A Virus, H1N2 Subtype* / isolation & purification
Influenza A Virus, H3N2 Subtype* / classification
Influenza A Virus, H3N2 Subtype* / genetics
Influenza A Virus, H3N2 Subtype* / immunology
Influenza A Virus, H3N2 Subtype* / isolation & purification
Influenza, Human / epidemiology
Influenza, Human / virology*
Molecular Epidemiology
Neuraminidase / genetics
Neuraminidase / immunology
Phylogeny
Reassortant Viruses / genetics
Reassortant Viruses / isolation & purification
Sequence Analysis, DNA
United States

Substances

Antigens, Viral
Hemagglutinin Glycoproteins, Influenza Virus
Neuraminidase