Abstract
We have recently identified and characterized a Kruppel-like zinc finger protein (BERF-1), that functions as a repressor of beta enolase gene transcription. By interspecific backcross analysis the gene encoding BERF-1 was localized 4.7 cM proximal to the Mtv6 locus on mouse chromosome 16, and an isolated pseudogene was localized to mouse chromosome 8, about 5.3 cM distal to the D8Mit4 marker. Nucleotide sequence identity and chomosome location indicate that the gene encoding BERF-1 is the mouse homologue (Zfp148) of ZNF148 localized to human chromosome 3q21, a common translocation site in acute myeloid leukemia patients.
Publication types
- Research Support, Non-U.S. Gov't
MeSH terms
- Animals
- Base Sequence
- Chromosome Mapping*
- Chromosomes, Human, Pair 3*
- Conserved Sequence
- DNA Primers
- DNA, Complementary
- DNA-Binding Proteins / genetics
- Gene Expression Regulation, Enzymologic
- Genetic Markers
- Humans
- Hybrid Cells / physiology
- Kruppel-Like Transcription Factors
- Mice
- Phosphopyruvate Hydratase / genetics*
- Polymerase Chain Reaction
- Pseudogenes / genetics*
- Repressor Proteins*
- Transcription Factors / genetics
- Transcription, Genetic / genetics
- Zinc Fingers / genetics*
Substances
- DNA Primers
- DNA, Complementary
- DNA-Binding Proteins
- Genetic Markers
- Kruppel-Like Transcription Factors
- Repressor Proteins
- Transcription Factors
- Phosphopyruvate Hydratase