David Friedman

The hallmark symptom in probable Alzheimer's disease (PAD) is dramatic difficulty in storing and/or retrieving new information on tests of explicit or direct memory. However, in many studies of implicit or indirect memory, these same patients show repetition-priming magnitudes (i.e., facilitation of performance on the basis of previous experience) similar to that of normal controls. Recent studies of repetition priming have shown that PAD subjects have an intact event-related potential (ERP) repetition effect, which is thought to index indirect memory functioning. The present study was designed to test the effect of multiple repetitions of verbal stimuli on the ERPs of PAD patients. ERPs were recorded from 8 subjects with PAD, 8 age-matched elderly and 16 young healthy controls. Subjects were asked to make speeded but accurate choice responses to infrequently occurring animal words and frequently occurring nonanimal words, some of which repeated across three blocks of trials. Al...

A hypothesis of overfocused attention in obsessive‐compulsive disorder was investigated by measuring auditory event‐related potentials (ERPs) during a selective attention task. Unmedicated patients (n= 18) with this disorder showed significantly larger attention‐related processing negativity (PN), with earlier onset and longer duration, than did normal controls (n= 15). In the N200 region (160–250 ms), PN was larger in patients with fewer nonspecific neurological soft signs. This task, however, did not yield any group differences in mismatch negativity (N2a) or classical N200 (N2b). P300 amplitudes for attended targets were smaller for patient than normal groups, but the reverse was true for P300 and positive slow wave amplitudes for unattended nontargets. Collectively, these ERP abnormalities suggest a misallocation of cognitive resources. Because of the importance of the frontal lobe in the control of selective attention, PN enhancement in patients with obsessive‐compulsive disord...

The novelty P3 is an event-related potential component that is most often elicited by environmental sounds within the "novelty oddball" paradigm. Within the context of this paradigm, it is not clear if the novelty P3 can be elicited by deviant stimuli regardless of whether they serve as target or nontarget deviants, or to what extent the physical characteristics of the stimulus contributes to the amplitude of the novelty P3. The current study examines this issue by systematically switching target and nontarget deviants between environmental sounds and tonal stimuli. Participants were 36 young adults. Auditory stimuli were 48 unique tones and 48 unique environmental sounds presented under three experimental conditions. The results showed that target and nontarget deviants elicited novelty P3s with anterior and posterior aspects. The major determinant of the extent of the anterior aspect was the degree of difference between the physical characteristics of the deviant stimuli and the standards. By contrast, the major determinant of the posterior aspect was the task relevance of the deviant stimuli.

Event-related brain potentials (ERPs) were recorded from 10 young adults during a version of the continuous recognition memory paradigm. Words were presented after lags of either 2, 8 or 32 intervening items (equiprobable) following their first presentation, and subjects were required on each trial to make a choice: new (never presented previously) or old (previously presented) response. To assess the effect of probability of new to old items, words were presented in separate blocks with ratios of new to old of 2:1 and 1:1. Reaction time increased and successful recognition decreased systematically as the lag between first and second presentations of an item increased, supporting the distinction between primary (immediate memory) and secondary memory for verbal material. However, there were no systematic effects of item lag on the ERP components. ERPs to new items were characterized by larger N300 and smaller P300 amplitudes (from about 250 to 700 ms) than those to old items. These amplitude differences between old and new ERPs were interpreted as primarily reflecting repetition as opposed to semantic priming effects. These old/new effects did not interact with probability, suggesting that frequency of occurrence is not a major determinant the ERP old/new difference. Old items elicited a late negativity following the behavioral response that was interpreted as due to the presence of a "positive slow wave," with a frontally oriented distribution to new words that was absent in the ERPs to old words. Similarly, subtraction of ERPs elicited by new items that were subsequently unrecognized from those subsequently recognized, showed that underlying the ERP subsequent "memory effect" was a "frontal positive slow wave," dissociable from P300 on the basis of differences in scalp distribution. Since positive slow wave has been interpreted as reflecting "further processing," the data suggest that such processing, possibly similar to elaboration (Graf & Mandler, 1984), enhanced the probability of subsequent recognition.

A decrease in the frontal lobes' efficiency is supposed to play a role in age-related changes in cognitive function. If frontal lobes are involved in the maintenance of working memory, the elderly may require increased frontal activity because of more rapid memory decay. This is consistent with the fact that the P3 component of the eventrelated potential (ERP) has a more frontal orientation with increasing age. However, frontally distributed P3s are also observed in young people when novel stimuli are unexpectedly presented in an oddball paradigm. Young and old subjects were run in an auditory novelty oddball in which ERPs were recorded from 30 scalp sites. The young adults' P3s showed either a posterior (targets) or more frontally oriented (novels) scalp focus. The elderly were less accurate in their memory for the novel stimuli, and their P3s showed anterior and posterior foci to both targets and novels. The young adults' target P3s changed over time from a frontal to a posterior focus, whereas the old adults' did not. These results are consistent with decreased ability of the elderly to maintain the templates needed for stimulus categorization.

Researchers concerned with the development of cognitive functions are in need of standardized material that can be used with both adults and children. The present article provides normative measures for 400 line drawings viewed by 5- and 6-year-old children. The three variables obtained-name agreement, familiarity, and visual complexity-are important because of their potential effect on memory and other cognitive processes. The normative data collected in the present study indicate that young children are different from adults in both the name most frequently assigned and the number of alternative names provided. The alternative names given by the children are either coordinate names or names of objects that are visually similar to the pictured object. In addition, the failure (to name) rate is higher among young children compared to adults. Thus, we conclude that unequivocal interpretation of age-related differences in cognitive functions can be made only when age-appropriate pictorial stimuli are chosen.