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Analytical Expression for the NO Concentration Profile Following NONOate Decomposition in the Presence of Oxygen

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Oxygen Transport to Tissue XXXVIII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 923))

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Abstract

We have derived an analytical expression for the time dependent NO concentration from NONOate donors in the presence of oxygen for the process of NO release from NO donors following autoxidation. This analytical solution incorporates the kinetics of the releases with the autoxidation and is used to fit the simulated NO concentration profile to the experimental data. This allows one to determine the NO release rate constant, k 1, the NO release stoichiometric coefficient, v NO, and the NO autoxidation reaction rate constant, k 2. This analytical solution also allows us to predict the real NO concentration released from NO donors under aerobic conditions, while v NO is reportedly two under aerobic conditions, it falls to lower values in the presence of oxygen.

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Acknowledgments

I thank Professor Michael Wilson (University of Essex) for helpful discussion and help with manuscript preparation and Professor Peter Nicholls (University of Essex) for the experimental data.

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Authors and Affiliations

  1. Centre for English Language Education, University of Nottingham Ningbo China, Ningbo, 315100, China

    Zimei Rong

  2. Department of Built Environment, London South Bank University, London, SE1 0AA, UK

    Zhihui Ye

Authors
  1. Zimei Rong
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  2. Zhihui Ye
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Corresponding author

Correspondence to Zimei Rong .

Editor information

Editors and Affiliations

  1. Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China

    Qingming Luo

  2. Molecular Imaging Laboratory, Department of Radiology, Britton Chance Laboratory of Redox Imaging, Johnson Research Foundation, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Lin Z. Li

  3. Microvascular Measurements, St. Lorenzen, Italy

    David K. Harrison

  4. Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China

    Hua Shi

  5. ISOTT Historian, Ellicott City, Maryland, USA

    Duane F. Bruley

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Rong, Z., Ye, Z. (2016). Analytical Expression for the NO Concentration Profile Following NONOate Decomposition in the Presence of Oxygen. In: Luo, Q., Li, L., Harrison, D., Shi, H., Bruley, D. (eds) Oxygen Transport to Tissue XXXVIII. Advances in Experimental Medicine and Biology, vol 923. Springer, Cham. https://doi.org/10.1007/978-3-319-38810-6_57

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