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Changes in Healthy Human IgG Fc-Glycosylation after Birth and during Early Childhood

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† Leiden University Medical Center, Center for Proteomics and Metabolomics, 2300 RC Leiden, The Netherlands
‡ Erasmus MC, Pediatrics, 3000 CA Rotterdam, The Netherlands
§ Erasmus MC, Immunology, 3000 CA Rotterdam, The Netherlands
*E-mail: [email protected]. Tel: +31-71-52-68744.
Cite this: J. Proteome Res. 2016, 15, 6, 1853–1861
Publication Date (Web):May 10, 2016
https://doi.org/10.1021/acs.jproteome.6b00038
Copyright © 2016 American Chemical Society
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    Abstract

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    Glycosylation on the fragment crystallizable (Fc) region of immunoglobulin G (IgG) has a large influence on the interaction of the antibody with Fc gamma receptors (FcγRs). IgG consists of four subclasses that all have distinct affinities for the different FcγRs. Knowledge about the Fc-glycosylation in healthy human is valuable as reference for new biomarkers and in the design of biopharmaceuticals that rely on IgG Fc-glycosylation. Previously, subclass-specific characterization of IgG Fc-glycosylation was performed for healthy adults, pregnant women, and newborns. For young healthy children, however, the subclass-specific description of IgG Fc-glycosylation is still lacking. Therefore, we performed the IgG subclass-specific analysis of the Fc-glycosylation of 130 healthy humans between birth and 40 years of age, including 22 samples derived from the umbilical cords of newborns. The analysis was performed by a previously published matrix-assisted laser desorption/ionization (MALDI)-time-of-flight (TOF)-mass spectrometry (MS) workflow, including a derivatization step for the linkage-specific stabilization of sialic acids. The characterization revealed that when children start to produce their own IgG they have a decreased galactosylation, sialylation, and bisection and an increased fucosylation compared with newborns. During childhood, the fucosylation and sialylation decrease, whereas bisection increases and galactosylation stays constant.

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.jproteome.6b00038.

    • Figure S-1: Data quality. Figure S-2: Glycans and glycan traits plotted versus age 0.1 to 17, separated for sex. Figure S-3: Glycans and glycan traits plotted versus age 0.1 to 17, sexes combined. Figure S-4: Glycans and glycan traits per age class, separated for sex. Figure S-5: Glycans and glycan traits per age class, sexes combined. (PDF)

    • Table S-1: Derived trait calculations. Table S-2: Correlation coefficients between the IgG Fc-glycosylation features and age. Table S-3: Sex differences in IgG Fc N-glycosylation per age class. Table S-4: Comparison between IgG Fc-glycosylation found in umbilical cord samples and in the youngest age category. Table S-5: Comparison between IgG Fc-glycosylation found in umbilical cord samples and in the oldest age category. Table S-6: Overview of the relevant literature in which current results are embedded. (XLSX)

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    29. Tamas Pongracz, Gestur Vidarsson, Manfred Wuhrer. Antibody glycosylation in COVID-19. Glycoconjugate Journal 2022, 39 (3) , 335-344. https://doi.org/10.1007/s10719-022-10044-0
    30. Elizabeth Edwards, Maria Livanos, Anja Krueger, Anne Dell, Stuart M. Haslam, C. Mark Smales, Daniel G. Bracewell. Strategies to control therapeutic antibody glycosylation during bioprocessing: Synthesis and separation. Biotechnology and Bioengineering 2022, 119 (6) , 1343-1358. https://doi.org/10.1002/bit.28066
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    37. Haifeng Hou, Huan Yang, Pengcheng Liu, Changwu Huang, Meng Wang, Yuejin Li, Mingsong Zhu, Jing Wang, Yuan Xu, Youxin Wang, Qingwei Ma, Dong Li, Pu Liao, Wei Wang. Profile of Immunoglobulin G N-Glycome in COVID-19 Patients: A Case-Control Study. Frontiers in Immunology 2021, 12 https://doi.org/10.3389/fimmu.2021.748566
    38. Mari Johnson, Lisa Stockdale, Noortje de Haan, Manfred Wuhrer, Jan Nouta, Carolien A. M. Koeleman, Jenny Clarke, Spyridoula Marinou, Mila Shakya, Rachel Colin-Jones, Katherine Theiss-Nyland, Merryn Voysey, Celina Jin, Dikshya Pant, Elizabeth Jones, Sarah Kelly, Sabina Dongol, Abhilasha Karkey, Shrijana Shrestha, Buddha Basnyat, Jennifer Hill, Andrew J. Pollard. Association of Antibody-Dependent Neutrophil Phagocytosis With Distinct Antibody Glycosylation Profiles Following Typhoid Vaccination. Frontiers in Tropical Diseases 2021, 2 https://doi.org/10.3389/fitd.2021.742804
    39. David J. Harvey. ANALYSIS OF CARBOHYDRATES AND GLYCOCONJUGATES BY MATRIX‐ASSISTED LASER DESORPTION/IONIZATION MASS SPECTROMETRY: AN UPDATE FOR 2015–2016. Mass Spectrometry Reviews 2021, 40 (4) , 408-565. https://doi.org/10.1002/mas.21651
    40. Willianne Hoepel, Hung-Jen Chen, Chiara E. Geyer, Sona Allahverdiyeva, Xue D. Manz, Steven W. de Taeye, Jurjan Aman, Lynn Mes, Maurice Steenhuis, Guillermo R. Griffith, Peter I. Bonta, Philip J.M. Brouwer, Tom G. Caniels, Karlijn van der Straten, Korneliusz Golebski, René E. Jonkers, Mads D. Larsen, Federica Linty, Jan Nouta, Cindy P.A.A. van Roomen, Frank E.H.P. van Baarle, Cornelis M. van Drunen, Gertjan Wolbink, Alexander P.J. Vlaar, Godelieve J. de Bree, Rogier W. Sanders, Lisa Willemsen, Annette E. Neele, Diederik van de Beek, Theo Rispens, Manfred Wuhrer, Harm Jan Bogaard, Marit J. van Gils, Gestur Vidarsson, Menno de Winther, Jeroen den Dunnen. High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages. Science Translational Medicine 2021, 13 (596) https://doi.org/10.1126/scitranslmed.abf8654
    41. Beatrix Paton, Manuel Suarez, Pol Herrero, Núria Canela. Glycosylation Biomarkers Associated with Age-Related Diseases and Current Methods for Glycan Analysis. International Journal of Molecular Sciences 2021, 22 (11) , 5788. https://doi.org/10.3390/ijms22115788
    42. Anika Mijakovac, Julija Jurić, Wendy M. Kohrt, Jasminka Krištić, Domagoj Kifer, Kathleen M. Gavin, Karlo Miškec, Azra Frkatović, Frano Vučković, Marija Pezer, Aleksandar Vojta, Peter A. Nigrović, Vlatka Zoldoš, Gordan Lauc. Effects of Estradiol on Immunoglobulin G Glycosylation: Mapping of the Downstream Signaling Mechanism. Frontiers in Immunology 2021, 12 https://doi.org/10.3389/fimmu.2021.680227
    43. Mads Delbo Larsen, Erik L. de Graaf, Myrthe E. Sonneveld, H. Rosina Plomp, Jan Nouta, Willianne Hoepel, Hung-Jen Chen, Federica Linty, Remco Visser, Maximilian Brinkhaus, Tonći Šuštić, Steven W. de Taeye, Arthur E. H. Bentlage, Suvi Toivonen, Carolien A. M. Koeleman, Susanna Sainio, Neeltje A. Kootstra, Philip J. M. Brouwer, Chiara Elisabeth Geyer, Ninotska I. L. Derksen, Gertjan Wolbink, Menno de Winther, Rogier W. Sanders, Marit J. van Gils, Sanne de Bruin, Alexander P. J. Vlaar, , , Theo Rispens, Jeroen den Dunnen, Hans L. Zaaijer, Manfred Wuhrer, C. Ellen van der Schoot, Gestur Vidarsson, Michiel van Agtmael, Anne Geke Algera, Frank van Baarle, Diane Bax, Diederik van de Beek, Martijn Beudel, Harm Jan Bogaard, Peter I. Bonta, Marije Bomers, Lieuwe Bos, Michela Botta, Godelieve de Bree, Matthijs C. Brouwer, Justin Brabander, Sanne de Bruin, Marianna Bugiani, Esther Bulle, Osoul Chouchane, Alex Cloherty, Paul Elbers, Lucas Fleuren, Suzanne Geerlings, Bart Geerts, Theo Geijtenbeek, Armand Girbes, Bram Goorhuis, Martin P. Grobusch, Florianne Hafkamp, Laura Hagens, Jorg Hamann, Vanessa Harris, Robert Hemke, Sabine M. Hermans, Leo Heunks, Markus W. Hollmann, Janneke Horn, Joppe W. Hovius, Menno de Jong, Rutger Koning, Niels van Mourik, Jeaninne Nellen, Esther J. Nossent, Frederique Paulus, Edgar Peters, Tom van der Poll, Bennedikt Preckel, Jan M. Prins, Jorinde Raasveld, Tom Rijnders, Michiel Schinkel, Marcus Schultz, Alex R. Schuurmans, Kim Sigaloff, Marry Smit, Cornelis S. Stijnis, Willemke Stilma, Charlotte Teunissen, Patrick Thoral, Anissa Tsonas, Marc van der Valk, Denise Veelo, Alexander P. J. Vlaar, Heder de Vries, Michèle van Vugt, W. Joost Wiersinga, Dorien Wouters, A. H. (Koos) Zwinderman. Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity. Science 2021, 371 (6532) https://doi.org/10.1126/science.abc8378
    44. Astrid Hagelkruys, Gerald Wirnsberger, Johannes Stadlmann, Miriam Wöhner, Marion Horrer, Bojan Vilagos, Gustav Jonsson, Melanie Kogler, Luigi Tortola, Maria Novatchkova, Peter Bönelt, David Hoffmann, Rubina Koglgruber, Ulrike Steffen, Georg Schett, Meinrad Busslinger, Andreas Bergthaler, Christoph Klein, Josef M. Penninger. A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans. Journal of Experimental Medicine 2021, 218 (1) https://doi.org/10.1084/jem.20200559
    45. Saborni Chakraborty, Joseph Gonzalez, Karlie Edwards, Vamsee Mallajosyula, Anthony S. Buzzanco, Robert Sherwood, Cindy Buffone, Nimish Kathale, Susan Providenza, Markus M. Xie, Jason R. Andrews, Catherine A. Blish, Upinder Singh, Haley Dugan, Patrick C. Wilson, Tho D. Pham, Scott D. Boyd, Kari C. Nadeau, Benjamin A. Pinsky, Sheng Zhang, Matthew J. Memoli, Jeffery K. Taubenberger, Tasha Morales, Jeffrey M. Schapiro, Gene S. Tan, Prasanna Jagannathan, Taia T. Wang. Proinflammatory IgG Fc structures in patients with severe COVID-19. Nature Immunology 2021, 22 (1) , 67-73. https://doi.org/10.1038/s41590-020-00828-7
    46. Marina Martinić Kavur, Gordan Lauc, Marija Pezer. Systems Glycobiology: Immunoglobulin G Glycans as Biomarkers and Functional Effectors in Aging and Diseases. 2021, 439-478. https://doi.org/10.1016/B978-0-12-819475-1.00086-9
    47. Kaitlyn A. Lagattuta, Peter A. Nigrovic. Estrogen-Driven Changes in Immunoglobulin G Fc Glycosylation. 2021, 341-361. https://doi.org/10.1007/978-3-030-76912-3_11
    48. Pranay Bharadwaj, Margaret E. Ackerman. Glycosylation of Antigen-Specific Antibodies: Perspectives on Immunoglobulin G Glycosylation in Vaccination and Immunotherapy. 2021, 565-587. https://doi.org/10.1007/978-3-030-76912-3_18
    49. Ana Cindrić, Jasminka Krištić, Marina Martinić Kavur, Marija Pezer. Glycosylation and Aging. 2021, 341-373. https://doi.org/10.1007/978-3-030-70115-4_17
    50. Falk Nimmerjahn, Anja Werner. Sweet Rules: Linking Glycosylation to Antibody Function. 2021, 365-393. https://doi.org/10.1007/978-3-030-76912-3_12
    51. Ligong Lu, Hui Zhang, Meixiao Zhan, Jun Jiang, Hua Yin, Danielle J. Dauphars, Shi-You Li, Yong Li, You-Wen He. Antibody response and therapy in COVID-19 patients: what can be learned for vaccine development?. Science China Life Sciences 2020, 63 (12) , 1833-1849. https://doi.org/10.1007/s11427-020-1859-y
    52. Jing Han, Yiqing Pan, Wenjun Qin, Yong Gu, Xiaoyan Xu, Ran Zhao, Jichen Sha, Rongrong Zhang, Jianxin Gu, Shifang Ren. Quantitation of sex-specific serum N-glycome changes in expression level during mouse aging based on Bionic Glycome method. Experimental Gerontology 2020, 141 , 111098. https://doi.org/10.1016/j.exger.2020.111098
    53. Lydia Su Yin Wong, Evelyn Xiu Ling Loo, Alicia Yi Hui Kang, Hui Xing Lau, Paul Anantharajah Tambyah, Elizabeth Huiwen Tham. Age-Related Differences in Immunological Responses to SARS-CoV-2. The Journal of Allergy and Clinical Immunology: In Practice 2020, 8 (10) , 3251-3258. https://doi.org/10.1016/j.jaip.2020.08.026
    54. Jing Han, Yiqing Pan, Yong Gu, Xiaoyan Xu, Ran Zhao, Jichen Sha, Rongrong Zhang, Jianxin Gu, Shifang Ren. Profiling of IgG N-glycome during mouse aging: Fucosylated diantennary glycans containing one Neu5Gc-linked LacNAc are associated with age. Journal of Proteomics 2020, 229 , 103966. https://doi.org/10.1016/j.jprot.2020.103966
    55. Agnes L. Hipgrave Ederveen, Noortje de Haan, Melissa Baerenfaenger, Dirk J. Lefeber, Manfred Wuhrer. Dissecting Total Plasma and Protein-Specific Glycosylation Profiles in Congenital Disorders of Glycosylation. International Journal of Molecular Sciences 2020, 21 (20) , 7635. https://doi.org/10.3390/ijms21207635
    56. Yong Zhang, Tianhai Lin, Yang Zhao, Yonghong Mao, Yiran Tao, Yan Huang, Shisheng Wang, Liqiang Hu, Jingqiu Cheng, Hao Yang. Characterization of N-linked intact glycopeptide signatures of plasma IgGs from patients with prostate carcinoma and benign prostatic hyperplasia for diagnosis pre-stratification. The Analyst 2020, 145 (15) , 5353-5362. https://doi.org/10.1039/D0AN00225A
    57. Amanda Tajik, Kaetlyn L. Phillips, Mark Nitz, Lisa M. Willis. A new ELISA assay demonstrates sex differences in the concentration of serum polysialic acid. Analytical Biochemistry 2020, 600 , 113743. https://doi.org/10.1016/j.ab.2020.113743
    58. Thomas F. Rice, Beth Holder, Beate Kampmann. Antibody glycosylation in pregnancy and in newborns. Current Opinion in Infectious Diseases 2020, 33 (3) , 225-230. https://doi.org/10.1097/QCO.0000000000000646
    59. Marta Wieczorek, Elena Ioana Braicu, Leticia Oliveira-Ferrer, Jahid Sehouli, Véronique Blanchard. Immunoglobulin G Subclass-Specific Glycosylation Changes in Primary Epithelial Ovarian Cancer. Frontiers in Immunology 2020, 11 https://doi.org/10.3389/fimmu.2020.00654
    60. Elisa B. Sodemann, Sabrina Dähling, Robert Klopfleisch, Ekaterina Boiarina, Didier Cataldo, Moumen M. Alhasan, Ali Ö. Yildirim, Martin Witzenrath, Christoph Tabeling, Melanie L. Conrad. Maternal asthma is associated with persistent changes in allergic offspring antibody glycosylation. Clinical & Experimental Allergy 2020, 50 (4) , 520-531. https://doi.org/10.1111/cea.13559
    61. Hao D. Cheng, Irit Tirosh, Noortje de Haan, Henning Stöckmann, Barbara Adamczyk, Ciara A. McManus, Róisín O’Flaherty, Gordon Greville, Radka Saldova, Francisco A. Bonilla, Luigi D. Notarangelo, Gertjan J. Driessen, Ingrid A. Holm, Pauline M. Rudd, Manfred Wuhrer, Margaret E. Ackerman, Peter A. Nigrovic. IgG Fc glycosylation as an axis of humoral immunity in childhood. Journal of Allergy and Clinical Immunology 2020, 145 (2) , 710-713.e9. https://doi.org/10.1016/j.jaci.2019.10.012
    62. Elisabeth A van Erp, Anke J Lakerveld, Erik de Graaf, Mads D Larsen, Rutger M Schepp, Agnes L Hipgrave Ederveen, Inge ML Ahout, Cornelis AM de Haan, Manfred Wuhrer, Willem Luytjes, Gerben Ferwerda, Gestur Vidarsson, Puck B van Kasteren. Natural killer cell activation by respiratory syncytial virus‐specific antibodies is decreased in infants with severe respiratory infections and correlates with Fc‐glycosylation. Clinical & Translational Immunology 2020, 9 (2) https://doi.org/10.1002/cti2.1112
    63. Dan Zhang, Xiaoou Li, Xiaofeng Liu, Yanmin Wang, Mo Zhang, Qing Wang, Tianjing Chen, Zhili Li. Disease‐Specific IgG Fc Glycosylation Ratios as Personalized Biomarkers to Differentiate Non‐Small Cell Lung Cancer from Benign Lung Diseases. PROTEOMICS – Clinical Applications 2020, 14 (1) https://doi.org/10.1002/prca.201900016
    64. Xueyan Cao, Yan Zheng, Shangyi Wu, Ning Yang, Junrui Wu, Biao Liu, Wenhui Ye, Mei Yang, Xiqing Yue. Characterization and comparison of milk fat globule membrane N -glycoproteomes from human and bovine colostrum and mature milk. Food & Function 2019, 10 (8) , 5046-5058. https://doi.org/10.1039/C9FO00686A
    65. Colin Reily, Tyler J. Stewart, Matthew B. Renfrow, Jan Novak. Glycosylation in health and disease. Nature Reviews Nephrology 2019, 15 (6) , 346-366. https://doi.org/10.1038/s41581-019-0129-4
    66. Nele Twisselmann, Yannic C. Bartsch, Julia Pagel, Christian Wieg, Annika Hartz, Marc Ehlers, Christoph Härtel. IgG Fc Glycosylation Patterns of Preterm Infants Differ With Gestational Age. Frontiers in Immunology 2019, 9 https://doi.org/10.3389/fimmu.2018.03166
    67. M. Vilaj, I. Gudelj, I. Trbojević-Akmačić, G. Lauc, M. Pezer. IgG Glycans as a Biomarker of Biological Age. 2019, 81-99. https://doi.org/10.1007/978-3-030-24970-0_7
    68. Ivan Gudelj, Gordan Lauc, Marija Pezer. Immunoglobulin G glycosylation in aging and diseases. Cellular Immunology 2018, 333 , 65-79. https://doi.org/10.1016/j.cellimm.2018.07.009
    69. Galit Alter, Tom H.M. Ottenhoff, Simone A. Joosten. Antibody glycosylation in inflammation, disease and vaccination. Seminars in Immunology 2018, 39 , 102-110. https://doi.org/10.1016/j.smim.2018.05.003
    70. Noortje de Haan, Navin P. Boeddha, Ebru Ekinci, Karli R. Reiding, Marieke Emonts, Jan A. Hazelzet, Manfred Wuhrer, Gertjan J. Driessen, . Differences in IgG Fc Glycosylation Are Associated with Outcome of Pediatric Meningococcal Sepsis. mBio 2018, 9 (3) https://doi.org/10.1128/mBio.00546-18
    71. Noortje de Haan, Maarten J. D. van Tol, Gertjan J. Driessen, Manfred Wuhrer, Arjan C. Lankester. Immunoglobulin G Fragment Crystallizable Glycosylation After Hematopoietic Stem Cell Transplantation Is Dissimilar to Donor Profiles. Frontiers in Immunology 2018, 9 https://doi.org/10.3389/fimmu.2018.01238
    72. Gillian Dekkers, Theo Rispens, Gestur Vidarsson. Novel Concepts of Altered Immunoglobulin G Galactosylation in Autoimmune Diseases. Frontiers in Immunology 2018, 9 https://doi.org/10.3389/fimmu.2018.00553
    73. Myrthe E. Sonneveld, Carolien A. M. Koeleman, H. Rosina Plomp, Manfred Wuhrer, C. Ellen van der Schoot, Gestur Vidarsson. Fc-Glycosylation in Human IgG1 and IgG3 Is Similar for Both Total and Anti-Red-Blood Cell Anti-K Antibodies. Frontiers in Immunology 2018, 9 https://doi.org/10.3389/fimmu.2018.00129
    74. Hao D Cheng, Henning Stöckmann, Barbara Adamczyk, Ciara A McManus, Altan Ercan, Ingrid A Holm, Pauline M Rudd, Margaret E Ackerman, Peter A Nigrovic. High-throughput characterization of the functional impact of IgG Fc glycan aberrancy in juvenile idiopathic arthritis. Glycobiology 2017, 27 (12) , 1099-1108. https://doi.org/10.1093/glycob/cwx082
    75. Noortje de Haan, Karli R. Reiding, Jasminka Krištić, Agnes L. Hipgrave Ederveen, Gordan Lauc, Manfred Wuhrer. The N-Glycosylation of Mouse Immunoglobulin G (IgG)-Fragment Crystallizable Differs Between IgG Subclasses and Strains. Frontiers in Immunology 2017, 8 https://doi.org/10.3389/fimmu.2017.00608
    76. Roy Jefferis. Recombinant Proteins and Monoclonal Antibodies. 2017, 281-318. https://doi.org/10.1007/10_2017_32
    77. Bas C. Jansen, Albert Bondt, Karli R. Reiding, Sicco A. Scherjon, Gestur Vidarsson, Manfred Wuhrer. MALDI-TOF-MS reveals differential N-linked plasma- and IgG-glycosylation profiles between mothers and their newborns. Scientific Reports 2016, 6 (1) https://doi.org/10.1038/srep34001
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