MMSL 2016, 85(2):69-74 | DOI: 10.31482/mmsl.2016.013

RENAL CELL LINES FOR STUDY OF NEPHROTOXICITY IN VITROReview article

Martina Vrbová, Eva Dastychová, Tomáš Roušar*
Faculty of Chemical Technology, University of Pardubice, Pardubice, Studentska 573, 532 10 Czech Republic

The kidneys are one of the organ that can be commonly damaged by a number of toxic compounds (heavy metals, xenobiotics, drugs, etc.). To characterize the mechanism of toxicity, a variety of methods have been developed. The in vitro methods belong among the mostly used. Especially, the use of cell lines seems to be the leading approach to test and to characterize the toxicity mechanisms. At present, several cell lines of animal (from rat, dog, pig) or human origin are available. A detailed evaluation must go before any selection of a suitable cell line for experiments. Therefore, the aim of this review was to describe and to evaluate the mostly used renal cell lines.

Keywords: Kidney; nephrotoxicity; cell lines; human kidney cells

Received: May 1, 2016; Revised: May 30, 2016; Published: June 14, 2016  Show citation

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Vrbová, M., Dastychová, E., & Roušar, T. (2016). RENAL CELL LINES FOR STUDY OF NEPHROTOXICITY IN VITRO. MMSL, 85(2), 69-74. doi: 10.31482/mmsl.2016.013
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