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Graphene Oxide–Polyethylenimine Nanoconstruct as a Gene Delivery Vector and Bioimaging Tool

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† Department of Chemistry, BK School of Molecular Science, Polymer Research Institute, Pohang University of Science and Technology, Pohang 790-784, Korea
‡ Division of Ocean Systems Engineering, School of Mechanical, Aerospace and Systems Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea
Department of Chemistry, Pohang University of Science and Technology, Pohang 790-784, Korea. Phone: 82-54-279-2104. Fax: 82-54-279-3399. E-mail: [email protected]
Cite this: Bioconjugate Chem. 2011, 22, 12, 2558–2567
Publication Date (Web):October 31, 2011
https://doi.org/10.1021/bc200397j
Copyright © 2011 American Chemical Society
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    Abstract

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    Graphene oxide (GO) has attracted an increasing amount of interest because of its potential applications in biomedical fields such as biological imaging, molecular imaging, drug/gene delivery, and cancer therapy. Moreover, GO could be fabricated by modifying its functional groups to impart specific functional or structural attributes. This study demonstrated the development of a GO-based efficient gene delivery carrier through installation of polyethylenimine, a cationic polymer, which has been widely used as a nonviral gene delivery vector. It was revealed that a hybrid gene carrier fabricated by conjugation of low-molecular weight branched polyethylenimine (BPEI) to GO increased the effective molecular weight of BPEI and consequently improved DNA binding and condensation and transfection efficiency. Furthermore, this hybrid material facilitated sensing and bioimaging because of its tunable and intrinsic electrical and optical properties. Considering the extremely high transfection efficiency comparable to that of high-molecular weight BPEI, high cell viability, and its application as a bioimaging agent, the BPEI–GO hybrid material could be extended to siRNA delivery and photothermal therapy.

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    Standard curve of BPEI quantification, ζ potentials of carriers, and confocal microscopic images of HeLa cells. This material is available free of charge via the Internet at http://pubs.acs.org.

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