Chapter 5
Structural Organization and Dynamics of Mitochondria in the Cells in Vivo
Andrey V. Kuznetsov,
Andrey V. Kuznetsov
Innsbruck Medical University, Department of General and Transplant Surgery, Daniel-Swarovski Research Laboratory, Innrain 66, 6020 Innsbruck, Austria
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Andrey V. Kuznetsov,
Andrey V. Kuznetsov
Innsbruck Medical University, Department of General and Transplant Surgery, Daniel-Swarovski Research Laboratory, Innrain 66, 6020 Innsbruck, Austria
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Book Editor(s):Prof. Valdur Saks,
Prof. Valdur Saks
J. Fourier University, Laboratory of Bioenergetics, 2280 rue de la Piscine, 38041 Grenoble Cedex 9, France
Université Joseph Fourier, Bioénergétique Fondamentale et Appliquée, INSERM U884, BP 53X, 38041 Grenoble Cedex, France
National Institute of Chemical and Biological Physics, Laboratory of Bioenergetics, Akadeemia tee 23, 12618 Tallinn, Estonia
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This chapter contains sections titled:
Abstract
Introduction
Intracellular Organization of Mitochondria
Multiple Functions of Mitochondria in the Cells in Vivo
Analysis of Mitochondrial Dynamics and Intracellular Organization in Vivo: Confocal Fluorescent Microscopy
Mitochondrial Clusters and Subpopulations, Mitochondrial Heterogeneity, and their Physiological and Pathophysiological Roles
Mitochondria as Discrete Units in Highly Differentiated Cells Versus the Mitochondrial Interconnected Network
Role of Mitochondrial Interactions with Other Intracellular Structures for Regulating Mitochondrial and Cellular Function
Tissue and Cell-type Specificity of Mitochondrial Intracellular Organization and Dynamics
Mitochondrial Dynamics: Regulation of Mitochondrial Morphology
Mitochondrial Shape Proteins
Mitochondrial Fusion and Fission
Mitochondrial Fragmentation During Apoptosis
Apoptotic Control and Mitochondrial Dynamics
The Importance of Spatial Mitochondrial Organization for Mediating Lethal Ca2+ Waves
Mitochondrial Dynamics: Mitochondrial Movement (Motility) in the Cell
Key Role of the Cytoskeleton and Specific Motor and Connector Proteins for Mitochondrial Movement
Motility of Mitochondria in Neurons
Concluding Remarks
References
References
- Kuznetsov, A.V., Mayboroda, O., Kunz, D., Winkler, K., Schubert, W., Kunz, W.S. (1998) Functional imaging of mitochondria in saponin-permeabilized mice muscle fibers. J. Cell. Biol. 140, 1091–1099.
- Romashko, D.N., Marban, E., O’Rourke, B. (1998) Subcellular metabolic transients and mitochondrial redox waves in heart cells. Proc. Natl. Acad. Sci. USA 95, 1618–1623.
- Appaix, F., Kuznetsov, A.V., Usson, Y., et al. (2003) Possible role of cytoskeleton in intracellular arrangement and regulation of mitochondria. Exp. Physiol. 88, 175–190.
- Andrienko, T., Kuznetsov, A.V., Kaambre, T., Usson, Y., Orosco, A., Appaix, F., Tiivel, T., Sikk, P., Vendelin, M., Margreiter, R., Saks, V.A. (2003) Metabolic consequences of functional complexes of mitochondria, myofibrils and sarcoplasmic reticulum in muscle cells. J. Exp. Biol. 206, 2059–2072.
- Anmann, T., Guzun, R., Beraud, N., Pelloux, S., Kuznetsov, A.V., Kogerman, L., Kaambre, T., Sikk, P., Paju, K., Peet, N., Seppet, E., Ojeda, C., Tourneur, Y., Saks, V. (2006) Different kinetics of the regulation of respiration in permeabilized cardiomyocytes and in HL-1 cardiac cells: Importance of cell structure/organization for respiration regulation. Biochim. Biophys. Acta 1757, 1597–1606.
- Huang, S., Heikal, A.A., Webb, W.W. (2002) Two-photon fluorescence spectroscopy and microscopy of NAD(P)H and flavoprotein. Biophys. J. 82, 2811–2825.
- Collins, T.J., Berridge, M.J., Lipp, P., Bootman, M.D. (2002) Mitochondria are morphologically and functionally heterogeneous within cells. EMBO J. 21, 1616–1627.
- Zorov, D.B., Filburn, C.R., Klotz, L.O., Zweier, J.L., Sollott, S.J. (2000) Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes. J. Exp. Med. 192, 1001–1014.
- Kuznetsov, A.V., Troppmair, J., Sucher, R., Hermann, M., Saks, V., Margreiter, R. (2006) Mitochondrial subpopulations and heterogeneity revealed by confocal imaging: possible physiological role? Biochim. Biophys. Acta 1757, 686–691.
- Anmann, T., Eimre, M., Kuznetsov, A.V., Andrienko, T., Kaambre, T., Sikk, P., Seppet, E., Tiivel, T., Vendelin, M., Seppet, E., Saks, V.A. (2005) Calcium–induced contraction of sarcomeres changes regulation of mitochondrial respiration in permeabilized cardiac cells. FEBS Journal 272, 3145–3161.
- Egner, A., Jakobs, S., Hell, S.W. (2002) Fast 100-nm resolution three-dimensional microscope reveals structural plasticity of mitochondria in live yeast. Proc Natl Acad Sci USA 99, 3370–3375.
- Kuznetsov, A.V., Usson, Y., Leverve, X., Margreiter, R. (2004) Subcellular heterogeneity of mitochondrial function and dysfunction: evidence by confocal imaging. Mol. Cel. Biochem. 256/257, 359–365.
- Kuznetsov, A.V., Schneeberger, S., Renz, O., Meusburger, H., Saks, V., Usson, Y., Margreiter, R. (2004) Functional heterogeneity of mitochondria after cardiac cold ischemia and reperfusion revealed by confocal imaging. Transplantation 77, 754–756.
- Bruce, J.I.E., Giovannucci, D.R., Blinder, G., Shuttleworth, T.J., Yule, D.I. (2004) Modulation of [Ca2+] i signaling dynamics and metabolism by perinuclear mitochondria in mouse parotid acinar cells. J. Biol. Chem. 279, 12909–12917.
- Dzeja, P.P., Bortolon, R., Perez-Terzic, C., Holmuhamedov, E.L., Terzic, A. (2002) Energetic communication between mitochondria and nucleus directed by catalyzed phosphotransfer. Proc. Natl. Acad. Sci. USA 99, 10156–10161.
- Rizzuto, R., Brini, M., Murgia, M., Pozzan, T. (1993) Microdomains with high Ca2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria. Science 262, 744–747.
- Rizzuto, R., Pinton, P., Carrington, W., Fay, F.S., Fogarty, K.E., Lifshitz, L.M., Tuft, R.A., Pozzan, T. (1998) Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses. Science 280, 1763–1766.
- Csordas, G., Thomas, A.P., Hajnoczky, G. (1999) Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria. EMBO J. 18, 96–108.
- Pacher, P., Hajnoczky, G. (2001) Propagation of the apoptotic signal by mitochondrial waves. EMBO J. 20, 4107–4121.
- Lawrie, A.M., Rizzuto, R., Pozzan, T., Simpson, A.W. (1996) A role for calcium influx in the regulation of mitochondrial calcium in endothelial cells. J. Biol. Chem. 271, 10753–10759.
- Bowser, D.N., Minamikawa, T., Nagley, P., Williams, D.A. (1998) Role of mitochondria in calcium regulation of spontaneously contracting cardiac muscle cells. Biophys. J. 75, 2004–2014.
- Chen, H., Chomyn, A., Chan, D.C. (2005) Disruption of fusion results in mitochondrial heterogeneity and dysfunction. J. Biol. Chem. 280, 26185–26192.
- Amchenkova, A.A., Bakeeva, L.E., Chentsov, Y.S., Skulachev, V.P., Zorov, D.B. (1988) Coupling membranes as energy-transmitting cables. I. Filamentous mitochondria in fibroblasts and mitochondrial clusters in cardiomyocytes. J. Cell. Biol. 107, 481–495.
- Skulachev, V.P. (2001) Mitochondrial filaments and clusters as intracellular power-transmitting cables. Trends Biochem. Sci. 26, 23–29.
- Knowles, M.K., Guenza, M.G., Capaldi, R.A., Marcus, A.H. (2002) Cytoskeletal-assisted dynamics of the mitochondrial reticulum in living cells. Proc. Natl. Acad. Sci. USA 99, 14772–14777.
- Davidson, M.T., Garland, P.B. (1975) Mitochondrial structure studied by high voltage electron microscopy of thick sections of Candida utilis. J. Gen. Microbiol. 91, 127–138.
- Leist, M., Single, B., Castoldi, A.F., Kuhnle, S., Nicotera, P. (1997) Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis. J. Exp. Med. 185, 1481–1486.
- Anesti, V., Scorrano, L. (2006) The relationship between mitochondrial shape and function and the cytoskeleton. Biochim. Biophys. Acta 1757, 692–699.
- Ball, E.H., Singer, S.J. (1982) Mitochondria are associated with microtubules and not with intermediate filaments in cultured fibroblasts. Proc. Natl. Acad. Sci. USA 79, 123–126.
- Mose-Larsen, P., Bravo, R., Fey, S.J., Small, J.V., Celis, J.E. (1982) Putative association of mitochondria with a subpopulation of intermediate-sized filaments in cultured human skin fibroblasts. Cell 31, 681–692.
- Hirokawa, N. (1982) Cross-linker system between neurofilaments, microtubules and membranous organelles in frog axons revealed by quick-freeze, deep etching method. J. Cell. Biol. 94, 129–142.
- Heggeness, M.H., Simon, M., Singer, S.J. (1978) Association of mitochondria with microtubules in cultured cells. Proc. Natl. Acad. Sci. USA 75, 3863–3866.
- Smith, M.G., Simon, V.R., O’Sullivan, H., Pon, L.A. (1995) Organellecytoskeletal interactions: Actin mutations inhibit meiosis-dependent mitochondrial rearrangement in the budding yeast. Saccharomyces cerevisiae Mol. Biol. Cell. 6, 1381–1396.
- Sun, J., Bird, C.H., Salem, H.H., Bird, P. (1993) Association of annexin V with mitochondria. FEBS Lett. 329, 79–83.
- Milner, D.J., Mavroidis, M., Weisleder, N., Capetanaki, Y. (2000) Desmin cytoskeleton linked to muscle mitochondrial distribution and respiratory function. J. Cell. Biol. 150, 1283–1298.
- Vendelin, M., Beraud, N., Guerrero, K., Andrienko, T., Kuznetsov, A.V., Olivares, J., Kay, L., Saks, V.A. (2005) Mitochondrial regular arrangement in muscle cells: a ‘‘crystal-like’’pattern. Am. J. Physiol. Cell. Physiol. 288, C757–C767.
- Seppet, E., Kaambre, T., Sikk, P., Tiivel, T., Vija, H., Kay, L., Appaix, F., Tonkonogi, M., Sahlin, K., Saks, V.A. (2001) Functional complexes of mitochondria with MgATPases of myofibrils and sarcoplasmic reticulum in muscle cells. Biochim. Biophys. Acta 1504, 379–395.
- Kaasik, A., Veksler, V., Boehm, E., Novotova, M., Minajeva, A., Ventura-Clapier, R. (2001) Energetic crosstalk between organelles. Architectural integration of energy production and utilization. Circ. Res. 89, 153–159.
- Kay, L., Li, Z., Mericskay, M., Olivares, J., Tranqui, L., Fontaine, E., Tiivel, T., Sikk, P., Kaambre, T., Samuel, J.L., Rappaport, L., Usson, Y., Leverve, X., Paulin, D., Saks, V.A. (1997) Study of regulation of mitochondrial respiration in vivo. An analysis of influence of ADP diffusion and possible role of cytoskeleton. Biochim. Biophys. Acta. 1322, 41–59.
- Saks, V., Kuznetsov, A.V., Andrienko, T., Usson, Y., Appaix, F., Guerrero, K., Kaambre, T., Sikk, P., Lemba, M., Vendelin, M. (2003) Heterogeneity of ADP diffusion and regulation of respiration in cardiac cells. Biophys. J. 84, 3436–3456.
- Yi, M., Weaver, D., Hajnoczky, G. (2004) Control of mitochondrial motility and distribution by the calcium signal: a homeostatic circuit. J. Cell. Biol. 167, 661–72.
- Yaffe, M.P. (1999) Dynamic mitochondria. Nat. Cell. Biol. 1, E149–E150.
- Karbowski, M., Youle, R.J. (2003) Dynamics of mitochondrial morphology in healthy cells and during apoptosis. Cell Death and Differentiation 10, 870–880.
- Perfettini, J.L., Roumier, T., Kroemer, G. (2005) Mitochondrial fusion and fission in the control of apoptosis. TRENDS in Cell Biology 15, 179–183.
- Griparic, L., van der Wel, N.N., Orozco, I.J., Peters, P.J., van der Bliek, A.M. (2004) Loss of the intermembrane space protein Mgm1/OPA1 induces swelling and localized constrictions along the lengths of mitochondria. J. Biol. Chem. 279, 18792–18798.
- Chen, H., Chan, D.C. (2005) Emerging functions of mammalian mitochondrial fusion and fission. Hum. Mol. Genet. 14, R283–R289.
- Smirnova, E., Griparic, L., Shurland, D.L., van der Bliek, A.M. (2001) Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells. Mol. Biol. Cell. 12, 2245–2256.
- Sesaki, H., Jensen, R.E. (1999) Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape. J. Cell. Biol. 147, 699–706.
- Burgess, S.M., Delannoy, M., Jensen, R.E. (1994) MMM1 encodes a mitochondrial outer membrane protein essential for establishing and maintaining the structure of yeast mitochondria. J. Cell. Biol. 126, 1375–1391.
- Jensen, R.E. (2005) Control of mitochondrial shape. Curr. Opin. Cell. Biol. 17, 384–388.
- Berger, K.H., Sogo, L.F., Yaffe, M.P. (1997) Mdm12p, a component required for mitochondrial inheritance that is conserved between budding and fission yeast. J. Cell. Biol. 136, 545–553.
- Dimmer, K.S., Jakobs, S., Vogel, F., Altmann, K., Westermann, B. (2005) Mdm31 and Mdm32 are inner membrane proteins required for maintenance of mitochondrial shape and stability of mitochondrial DNA nucleoids in yeast. J. Cell. Biol. 168, 103–115.
- Sogo, L.F., Yaffe, M.P. (1994) Regulation of mitochondrial morphology and inheritance by Mdm10p, a protein of the mitochondrial outer membrane. J. Cell. Biol. 126, 1361–1373.
- Youngman, M.J., Hobbs, A.E., Burgess, S.M., Srinivasan, M., Jensen, R.E. (2004) Mmm2p, a mitochondrial outer membrane protein required for yeast mitochondrial shape and maintenance of mtDNA nucleoids. J. Cell. Biol. 164, 677–688.
- Frederick, R.L., McCaffery, J.M., Cunningham, K.W., Okamoto, K., Shaw, J.M. (2004) Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via a novel pathway. J. Cell. Biol. 167, 87–98.
- John, G.B., Shang, Y., Li, L., Renken, C., Mannella, C.A., Selker, J.M., Rangell, L., Bennett, M.J., Zha, J. (2005) The mitochondrial inner membrane protein mitofilin controls cristae morphology. Mol. Biol. Cell. 16, 1543–1554.
- Paumard, P., Vaillier, J., Coulary, B., Schaeffer, J., Soubannier, V., Mueller, D.M., Brethes, D., di Rago, J.P., Velours, J. (2002) The ATP synthase is involved in generating mitochondrial cristae morphology. EMBO J. 21, 221–230.
- Thomson, M. (2002) The regulation of mitochondrial physiology by organelle-associated GTP-binding proteins. Cell. Biochem. Funct. 20, 273–278.
- Rossignol, R., Gilkerson, R., Aggeler, R., Yamagata, K., Remington, S.J., Capaldi, R.A. (2004) Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells. Cancer Res. 64, 985–993.
- Mozdy, A.D., Shaw, J.M. (2003) A fuzzy mitochondrial fusion apparatus comes into focus. Nat. Rev. Mol. Cell. Biol. 4, 468–78.
- Bleazard, W., McCaffery, J.M., King, E.J., Bale, S., Mozdy, A., Tieu, Q., Nunnari, J., Shaw, J.M. (1999) The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast. Nat. Cell. Biol. 1, 298–304.
- James, D.I., Parone, P.A., Mattenberger, Y., Martinou, J.C. (2003) hFis1, a novel component of the mammalian mitochondrial fission machinery. J. Biol. Chem. 278, 36373–36379.
- Chen, H., Detmer, S.A., Ewald, A.J., Griffin, E.E., Fraser, S.E., Chan, D.C. (2003) Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J. Cell. Biol. 160, 189–200.
- Cipolat, S., Martins de Brito, O., Dal Zilio, B., Scorrano, L. (2004) OPA1 requires mitofusin 1 to promote mitochondrial fusion. Proc. Natl. Acad. Sci. USA 101, 15927–15932.
- Hermann, G.J., Thatcher, J.W., Mills, J.P., Hales, K.G., Fuller, M.T., Nunnari, J., Shaw, J.M. (1998) Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p. J. Cell. Biol. 143, 359–373.
- Cereghetti, G.M., Scorrano, L. (2006) The many shapes of mitochondrial death. Oncogene 25, 4717–4724.
- Griffin, E.E., Graumann, J., Chan, D.C. (2005) The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria. J. Cell Biol. 170, 237–248.
- Zuchner, S., Mersiyanova, I.V., Muglia, M., Bissar-Tadmouri, N., Rochelle, J., Dadali, E.L., Zappia, M., Nelis, E., et al. (2004) Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot–Marie–Tooth neuropathy type 2A. Nat. Genet. 36, 449–451.
- Alexander, C., Votruba, M., Pesch, U.E., Thiselton, D.L., Mayer, S., Moore, A., Rodriguez, M., Kellner, U., et al. (2000) OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28. Nat. Genet. 26, 211–215.
- Ishihara, N., Jofuku, A., Eura, Y., Mihara, K. (2003) Mitochondrial fusion is completely inhibited by protonophores that dissipate the inner membrane potential. Biochem. Biophys. Res. Commun. 301, 891–898.
- Frank, S., Gaume, B., Bergmann-Leitner, E.S., Leitner, W.W., Robert, E.G., Catez, F., Smith, C.L., Youle, R.J. (2001) The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Dev. Cell. 1, 515–525.
- Breckenridge, D.G., Stojanovic, M., Marcellus, R.C., Shore, G.C. (2003) Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol. J. Cell. Biol. 160, 1115–1127.
- Lee, Y.J., Jeong, S.Y., Karbowski, M., Smith, C.L., Youle, R.J. (2004) Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. Mol. Biol. Cell. 15, 5001–5011.
- Youle, R.J., Karbowski, M. (2005) Mitochondrial fission in apoptosis. Nat. Rev. Mol. Cell. Biol. 6, 657–663.
- Karbowski, M., Lee, Y.-J., Gaume, B., Jeong, S.-Y., Frank, S., Nechushtan, A., Santel, A., Fuller, M., Smith, C.L., Youle, R.J. (2002) Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis. J. Cell. Biol. 159, 931–938.
- Takahashi, Y., Karbowski, M., Yamaguchi, H., Kazi, A., Wu, J., Sebti, S.M., Youle, R.J., Wang, H.G. (2005) Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis. Mol. Cell. Biol. 25, 9369–9382.
- Karbowski, M., Norris, K.L., Cleland, M.M., Jeong, S.Y., Youle, R.J. (2006) Role of Bax and Bak in mitochondrial morphogenesis. Nature 443, 658–662.
- Olichon, A., Baricault, L., Gas, N., Guillou, E., Valette, A., Belenguer, P., Lenaers, G. (2002) Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis. J. Biol. Chem. 278, 7743–7746.
- Boldogh, I.R., Pon, L.A. (2006) Interactions of mitochondria with the actin cytoskeleton. Biochim. Biophys. Acta 1763, 450–462.
- Tang, H.L., Le, A.H., Lung, H.L. (2006) The increase in mitochondrial association with actin precedes Bax translocation in apoptosis. Biochem. J. 396, 1–5.
- Pacher, P., Hajnoczky, G. (2001) Propagation of the apoptotic signal by mitochondrial waves. EMBO J. 20, 4107–4121.
- Szabadkai, G., Simoni, A.M., Chami, M., Wieckowski, M.R., Youle, R.J., Rizzuto, R. (2004) Drp-1-dependent division of the mitochondrial network blocks intraorganellar Ca2+ waves and protects against Ca2+-mediated apoptosis. Mol. Cell. 16, 59–68.
- Hollenbeck, P.J., Saxton, W.M. (2005) The axonal transport of mitochondria. J. Cell. Sci. 118, 5411–5419.
- Simon, V.R., Swayne, T.C., Pon, L.A. (1995) Actin-dependent mitochondrial motility in mitotic yeast and cell-free systems: identification of a motor activity on the mitochondrial surface. J. Cell. Biol. 130, 345–354.
- Fehrenbacher, K.L., Yang, H.C., Gay, A.C., Huckaba, T.M., Pon, L.A. (2004) Live cell imaging of mitochondrial movement along actin cables in budding yeast. Curr. Biol. 14, 1996–2004.
- Bantseev, V., Sivak, J.G. (2005) Confocal laser scanning microscopy imaging of dynamic TMRE movement in the mitochondria of epithelial and superficial cortical fiber cells of bovine lenses. Mol. Vis. 11, 518–523.
- Park, M.K., Ashby, M.C., Erdemli, G., Petersen, O.H., Tepikin, A.V. (2001) Perinuclear, perigranular and subplasmalemmal mitochondria have distinct functions in the regulation of cellular calcium transport. EMBO J. 20, 1863–1874.
- Vale, R.D., Funatsu, T., Pierce, D.W., Romberg, L., Harada, Y., Yanagida, T. (1996) Direct observation of single kinesin molecules moving along microtubules. Nature 380, 451–453.
- Vale, R.D. (2003) The molecular motor toolbox for intracellular transport. Cell 112, 467–480.
- Brady, S.T., Lasek, R.J., Allen, R.D. (1982) Fast axonal transport in extruded axoplasm from squid giant axon. Science 218, 1129–1131.
- Pereira, A.J., Dalby, B., Stewart, R.J., Doxsey, S.J., Goldstein, L.S. (1997) Mitochondrial association of a plus end-directed microtubule motor expressed during mitosis in Drosophila. J. Cell Biol. 136, 1081–1090.
- Stowers, R.S., Megeath, L.J., GorskaAndrzejak, J., Meinertzhagen, I.A., Schwarz, T.L. (2002) Axonal transport of mitochondria to synapse depends on milton, a novel Drosophila protein. Neuron 36, 1063–1077.
- Boldogh, I.R., Yang, H.C., Nowakowski, W.D., Karmon, S.L., Hays, L.G., Yates, 3rd J.R., Pon, L.A. (2001) Arp2/3 complex and actin dynamics are required for actin-based mitochondrial motility in yeast. Proc. Natl. Acad. Sci. USA 98, 3162–3167.
- Smith, M.G., Simon, V.R., O’Sullivan, H., Pon, L.A. (1995) Organellecytoskeletal interactions: actin mutations inhibit meiosis-dependent mitochondrial rearrangement in the budding yeast. Saccharomyces cerevisiae Mol. Biol. Cell. 6, 1381–1396.
- Suelmann, R., Fischer, R. (2000) Mitochondrial movement and morphology depend on an intact actin cytoskeleton in Aspergillus nidulans. Cell. Motil. Cytoskeleton 45, 42–50.
- Sturmer, K., Baumann, O., Walz, B. (1995) Actin-dependent light-induced translocation of mitochondria and ER cisternae in the photoreceptor cells of the locust Schistocerca gregaria. J. Cell. Sci. 108, 2273–2283.
- Van Gestel, K., Kohler, R.H., Verbelen, J.P. (2002) Plant mitochondria move on F-actin, but their positioning in the cortical cytoplasm depends on both Factin and microtubules. J. Exp. Bot. 53, 659–667.
- Morris, R.L., Hollenbeck, P.J. (1995) Axonal transport of mitochondria along microtubules and F-actin in living vertebrate neurons. J. Cell. Biol. 131, 1315–1326.
- Varadi, A., Johnson-Cadwell, L.I., Cirulli, V., Yoon, Y., Allan, V.J., Rutter, G.A. (2004) Cytoplasmic dynein regulates the subcellular distribution of mitochondria by controlling the recruitment of the fission factor dynamin-related protein-1. J. Cell. Sci. 117, 4389–4400.
- Chang, D.T., Reynolds, I.J. (2006) Differences in mitochondrial movement and morphology in young and mature primary cortical neurons in culture. Neuroscience 141, 727–736.
- Chada, S.R., Hollenbeck, P.J. (2003) Mitochondrial movement and positioning in axons: the role of growth factor signaling. J. Exp. Biol. 206, 1985–1992.
- Miller, K.E., Sheetz, M.P. (2004) Axonal mitochondrial transport and potential are correlated. J. Cell. Sci. 117, 2791–2804.
- Rintoul, G.L., Filiano, A.J., Brocard, J.B., Kress, G.J., Reynolds, I.J. (2003) Glutamate decreases mitochondrial size and movement in primary forebrain neurons. J. Neurosci. 23, 7881–7888.
- Li, Y.C., Zhai, X.Y., Ohsato, K., Futamata, H., Shimada, O., Atsumi, S. (2004) Mitochondrial accumulation in the distal part of the initial segment of chicken spinal motoneurons. Brain Res. 1026, 235–243.
- Trimmer, P.A., Swerdlow, R.H., Parks, J.K., Keeney, P., Bennett, J.P., Miller, S.W., Davis, R.E., Parker, W.D. (2000) Abnormal mitochondrial morphology in sporadic Parkinson’s and Alzheimer’s disease cybrid cell lines. Exp. Neurol. 162, 37–50.
- Delettre, C., Lenaers, G., Griffoin, J.M., Gigarel, N., Lorenzo, C., Belenguer, P., Pelloquin, L., Grosgeorge, J., Turc-Carel, C., Perret, E., Astarie-Dequeker, C., Lasquellec, L., Arnaud, B., Ducommun, B., Kaplan, J., Hamel, C.P. (2000) Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy. Nat. Genet. 26, 207–210.
- Olichon, A., Guillou, E., Delettre, C., Landes, T., Arnaune-Pelloquin, L., Emorine, L.J., Mils, V., Daloyau, M., Hamel, C., Amati-Bonneau, P., Bonneau, D., Reynier, P., Lenaers, G., Belenguer, P. (2006) Mitochondrial dynamics and disease. Biochim. Biophys. Acta 1763, 500–509.
- Sesaki, H., Jensen, R.E. (2001) UGO1 encodes an outer membrane protein required for mitochondrial fusion. J. Cell. Biol. 152, 1123–1134.
- Sesaki, H., Jensen, R.E. (2004) Ugo1p links the Fzo1p and Mgm1p GTPases for mitochondrial fusion. J. Biol. Chem. 279, 28298–28303.
- Alto, N.M., Soderling, J., Scott, J.D. (2002) Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics. J. Cell Biol. 158, 659–668.
- Messerschmitt, M., Jakobs, S., Vogel, F., Fritz, S., Dimmer, K.S., Neupert, W., Westermann, B. (2003) The inner membrane protein Mdm33 controls mitochondrial morphology in yeast. J. Cell Biol. 160, 553–564.
- Chen, W., Calvo, P.A., Malide, D., Gibbs, J., Schubert, U., Bacik, I., Basta, S., O’Neill, R., Schickli, J., Palese, P., Henklein, P., Bennink, J.R., Yewdell, J.W. (2001) A novel influenza A virus mitochondrial protein that induces cell death. Nat. Med. 7, 1306–1312.
- Nechushtan, A., Smith, C.L., Lamensdorf, I., Yoon, S.-H., Youle, R.J. (2001) Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis. J. Cell. Biol. 153, 1265–1276.
- Wolter, K.G., Hsu, Y.T., Smith, C.L., Nechushtan, A., Xi, X.G., Youle, R.J. (1997) Movement of Bax from the cytosol to mitochondria during apoptosis. J. Cell. Biol. 139, 1281–1292.
- Scorrano, L., Ashiya, M., Buttle, K., Weiller, S., Oakes, S.A., Mannella, C.A., Korsmeyer, S.J. (2002) A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis. Dev. Cell. 2, 55–67.
- Esposti, M.D., Erler, J.T., Hickman, J.A., Dive, C. (2001) Bid, a widely expressed proapoptotic protein of the Bcl-2 family, displays lipid transfer activity. Mol. Cell. Biol. 21, 7268–7276.
- Kowaltowski, A.J., Cosso, R.G., Campos, C.B., Fiskum, G. (2002) Effect of Bcl-2 overexpression on mitochondrial structure and function. J. Biol. Chem. 277, 42802–42807.
- Goldmacher, V.S., Bartle, L.M., Skaletskaya, A., Dionne, C.A., Kedersha, N.L., Vater, C.A., Han, J.-w., Lutz, R.J., Watanabe, S., Cahir McFarland, E.D., Kieff, E.D., Mocarski, E.S., Chittenden, T. (1999) A cytomegalovirus-encoded mitochondrialocalized inhibitor of apoptosis structurally unrelated to Bcl-2. Proc. Natl. Acad. Sci. USA 96, 12536–12541.
