Iodine Promoted Synthesis of S-Benzoazolyl Chromones by a Three-Component One-Pot Reaction
Graphical Abstract
A practical approach for the synthesis of S-benzoazolyl chromones was reported. Using iodine as oxidant, 2-hydroxyphenyl enaminones, tetramethylthiuram disulfide and 2-aminophenol as starting materials, various S-benzoazolyl chromones could be obtained by a one-pot manner.
Abstract
In the presence of iodine, the synthesis of S-benzoazolyl chromone derivatives by one-pot manner is reported. Thus, 2-aminophenol firstly reacted with tetramethylthiuram disulfide (TMTD) to form 2-mercaptobenzoxazole, and then coupled with 2-hydroxyphenyl enaminones to obtain S-benzoazolyl chromones through one-pot manner. This method features mild conditions, easy operation, environmentally friendliness and wide substrate scopes, illustrating practical application value in organic synthesis.
Conflict of interest
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available in the supplementary material of this article.
