Comment on "Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis"
Abstract
Taguchi et al. (Reports, 20 July 2007, p. 369) reported that mice heterozygous for a null mutation in insulin receptor substrate–2 (Irs2) display a 17% increase in median life span. However, using the same mouse model, we find no evidence for life-span extension and suggest that the findings of Taguchi et al. were due to atypical life-span profiles in their study animals.
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Published In
Science
Volume 320 | Issue 5879
23 May 2008
23 May 2008
Copyright
American Association for the Advancement of Science.
Submission history
Received: 30 October 2007
Accepted: 22 April 2008
Published in print: 23 May 2008
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www.sciencemag.org/cgi/content/full/320/5879/1012b/DC1
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