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Striatal glucose consumption in chorea-free subjects at risk of Huntington's disease

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Abstract

Controversial data have been reported with regard to the diagnostic value of the positron emission tomographic (PET) measurement of striatal glucose consumption (rCMRGlc) in chorea-free subjects at risk of Huntington's disease (HD). For further clarification of this issue we measured striatal and cerebellar rCMRGlc in 27 chorea-free subjects at risk of HD, 20 patients with manifest HD and 20 control subjects, using PET and18F-fluorodeoxyglucose. In 6 of the at-risk subjects cerebellar ratios of striatal rCMRGlc were decreased below the corresponding 99% confidence limit determined in the controls. This indicates that the PET measurement of rCMRGlc may, indeed, be valuable in establishing the diagnosis of incipient HD in presymptomatic at-risk subjects.

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Author notes

  1. H. Boecker

    Present address: Abteilung für Neurologie, Technische Universität München, Möhlstrasse, D-81675, München, Germany

  2. B. -C. Wang

    Present address: Jiangsu Institute of Nuclear Medicine, Quian Rong Rd., 214063, Wuxi, Iangsu, China

  3. U. Nayak

    Present address: Radiation Medicine Center, Jerbai Wadia Rd., 400012, Parel Bombay, India

Authors and Affiliations

  1. Institute of Medicine, Research Center, KFA Jülich, D-52425, Jülich, Germany

    T. Kuwert, H. Boecker, H. Titz, H. Herzog, B. -C. Wang, U. Nayak & L. E. Feinendegen

  2. Neurological Therapy Center, Düsseldorf, Germany

    H. W. Lange

  3. Department of Diagnostic Radiology, Heinrich-Heine-Universität, Düsseldorf, Germany

    A. Aulich

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  1. T. Kuwert
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  4. H. Herzog
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Kuwert, T., Boecker, H., Titz, H. et al. Striatal glucose consumption in chorea-free subjects at risk of Huntington's disease. J Neurol 241, 31–36 (1993). https://doi.org/10.1007/BF00870669

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  • DOI: https://doi.org/10.1007/BF00870669

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