Abstract
A null mutation for the Sod2 gene, Sod2n283, was obtained in Drosophila melanogaster. Homozygous Sod2 null (Sodn283/Sodn283) adult flies survive up to 24 hr following eclosion, a phenotype reminiscent of mice, where Sod2-/- progeny suffer neonatal lethality. Sodn283/+ heterozygotes are sensitive to oxidative stress induced by paraquat treatment.
Publication types
- Comparative Study
- Research Support, U.S. Gov't, P.H.S.
MeSH terms
- Animals
- Animals, Genetically Modified
- Drosophila melanogaster / drug effects
- Drosophila melanogaster / enzymology*
- Drosophila melanogaster / genetics*
- Female
- Genes, Lethal*
- Herbicides / toxicity
- Homozygote
- Life Expectancy
- Male
- Mutation*
- Oxidative Stress
- Paraquat / toxicity
- Phenotype
- Superoxide Dismutase / physiology*
- Survival Rate
Substances
- Herbicides
- Superoxide Dismutase
- Paraquat