Abstract
We have observed that respiratory virus infection of mice provokes an extremely persistent humoral immune reaction, due to a long-sustained population of antibody-secreting cells in the bone marrow. Theories of humoral immunity that strongly distinguish primary and secondary reactions thus may not adequately describe the immune response to respiratory viruses.
Publication types
- Research Support, Non-U.S. Gov't
- Research Support, U.S. Gov't, P.H.S.
MeSH terms
- Animals
- Antibodies, Viral / biosynthesis*
- Antibody Formation
- Antibody-Producing Cells
- Bone Marrow / immunology
- Bone Marrow Cells
- Influenza A virus / immunology*
- Mice
- Mice, Inbred C57BL
- Parainfluenza Virus 1, Human / immunology*
- Paramyxoviridae Infections / immunology*
- Time Factors