Designing New Protoporphyrinogen Oxidase-Inhibitors Carrying Potential Side Chain Isosteres to Enhance Crop Safety and Spectrum of Activity.
Alnafta N, Beffa R, Bojack G, Bollenbach-Wahl B, Brant NZ, Dörnbrack C, Dorn N, Freigang J, Gatzweiler E, Getachew R, Hartfiel C, Heinemann I, Helmke H, Hohmann S, Jakobi H, Lange G, Lümmen P, Willms L, Frackenpohl J. Alnafta N, et al. J Agric Food Chem. 2023 Nov 29;71(47):18270-18284. doi: 10.1021/acs.jafc.3c01420. Epub 2023 Jun 3. J Agric Food Chem. 2023. PMID: 37269295
By modifying structural key features from known PPO inhibitors such as tiafenacil, inspired by isostere and mix&match concepts in combination with modeling investigations based on a wild-type Amaranthus crystal structure, we have found new promising lead structures showing st …
By modifying structural key features from known PPO inhibitors such as tiafenacil, inspired by isostere and mix&match concepts in combin …