Abstract
Purpose
Melatonin has anti-carcinogenic properties, including modulation of estradiol production, cell cycle regulation, and promotion of apoptosis. Urinary melatonin has been inversely associated with breast cancer in some studies, but the association with ovarian cancer has not been investigated.
Methods
We measured urinary 6-sulfatoxymelatonin (aMT6s) in nested ovarian cancer case–control studies in the Nurses’ Health Study (NHS; n = 100 cases; 199 controls) and NHSII (n = 52 cases; 105 controls); samples were mainly from first morning voids. Controls were matched to cases on year of birth, menopause status, use of menopausal hormone therapy, and urine collection characteristics. We evaluated the association of tertiles of aMT6s, corrected for creatinine concentrations, with risk of ovarian cancer using conditional logistic regression. Models were adjusted for key ovarian cancer risk factors, and we additionally evaluated adjustment for usual sleep duration, snoring, and history of rotating night shift work.
Results
aMT6s was not significantly associated with risk of ovarian cancer. In multivariable models, the odds ratio comparing the highest tertile of aMT6s to the lowest was 0.79, 95 % confidence interval (CI) 0.40–1.56 in the NHS and 2.88, and 95 % CI in the NHSII 0.97–8.52. Additional adjustment for sleep habits and night shift work had little impact on the observed results. We observed no clear association between urinary melatonin and ovarian cancer risk.
Conclusions
These results are consistent with our previous study in which we reported no association between night shift work and ovarian cancer; however, given the small sample size in our study, additional evaluation in larger studies is warranted.
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Acknowledgments
We would like to thank the participants and staff of the Nurses’ Health Studies for their valuable contributions as well as the following state cancer registries for their help: AL, AZ, AR, CA, CO, CT, DE, FL, GA, ID, IL, IN, IA, KY, LA, ME, MD, MA, MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA, and WY. This work was supported by National Cancer Institute Grants UM1 CA186107, P01 CA87969, R01 CA49449, UM1 CA176726, and R01 CA67262.
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This analysis was approved by the institutional review board of Brigham and Women’s Hospital. Study participants provided informed consent.
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The authors have no conflicts of interest to disclose.
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Poole, E.M., Schernhammer, E., Mills, L. et al. Urinary melatonin and risk of ovarian cancer. Cancer Causes Control 26, 1501–1506 (2015). https://doi.org/10.1007/s10552-015-0640-2
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DOI: https://doi.org/10.1007/s10552-015-0640-2