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Mitochondrial dynamics and its impact on human health and diseases: inside the DRP1 blackbox

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Abstract

Mitochondria are essential organelles that play a significant role in various cellular processes apart from providing energy in eukaryotic cells. An intricate link between mitochondrial structure and function is now unequivocally accepted. Several molecular players have been identified, which are important in maintaining the structure of the organelle. Dynamin-related protein 1 (DRP1) is one such conserved protein that is a vital regulator of mitochondrial dynamics. Multidisciplinary studies have helped elucidate the structure of the protein and its mechanism of action in great detail. Mutations in various domains of the protein have been identified that are associated with debilitating conditions in patients. The involvement of the protein in disease conditions such as neurodegeneration, cancer, and cardiovascular disorders is also gaining attention. The purpose of this review is to highlight recent findings on the role of DRP1 in human disease conditions and address its importance as a therapeutic target.

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Acknowledgements

We thank all members of OBCAL for their inputs. Our sincere apologies to all our colleagues for any publication not being cited due to space limitation.

Funding

This work was supported by the Department of Biotechnology (DBT), Government of India (BT/PR25097/NER/95/1013/2017), and Top-up of start-up grant from IIT Guwahati.

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  1. Organelle Biology and Cellular Ageing Lab, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati-781039, Assam, India

    Riddhi Banerjee, Agradeep Mukherjee & Shirisha Nagotu

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  1. Riddhi Banerjee
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  2. Agradeep Mukherjee
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  3. Shirisha Nagotu
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RB performed the literature search, wrote the manuscript, and prepared the figures. AM prepared the tables and wrote the manuscript. SN wrote edited and conceived the concept for the manuscript. All authors read and approved the final manuscript.

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Correspondence to Shirisha Nagotu.

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Banerjee, R., Mukherjee, A. & Nagotu, S. Mitochondrial dynamics and its impact on human health and diseases: inside the DRP1 blackbox. J Mol Med 100, 1–21 (2022). https://doi.org/10.1007/s00109-021-02150-7

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