Journal of Food Science

Volume 75, Issue 9 p. M546-M551

Lactobacillus Fermentum Isolated from Human Colonic Mucosal Biopsy Inhibits the Growth and Adhesion of Enteric and Foodborne Pathogens

Parvathi Varma,

Parvathi Varma

Authors are with Amrita Inst. of Medical Sciences, Research Centre for Nanoscience and Molecular medicine, AIMS—Ponekkara, Edapally, Cochin, Kerala 682041, India. Direct inquiries to author Biswas (E-mail: [email protected] ).

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Kavitha R. Dinesh,

Kavitha R. Dinesh

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Krishna K. Menon,

Krishna K. Menon

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Raja Biswas,

Raja Biswas

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Parvathi Varma,

Parvathi Varma

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Kavitha R. Dinesh,

Kavitha R. Dinesh

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Krishna K. Menon,

Krishna K. Menon

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Raja Biswas,

Raja Biswas

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First published: 07 October 2010

https://doi.org/10.1111/j.1750-3841.2010.01818.x

Citations: 59

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Abstract

Abstract: A number of Lactobacillus species are used as probiotic strains in order to benefit health. We have isolated L. fermentum from human colonic mucosal biopsy samples that possess antimicrobial activities against entroinvasive and foodborne pathogens such as Escherichia coli, Salmonella paratyphi A, Shigella sonnei, Staphylococcus aureus, Enterococcus faecalis, Proteus mirabilis, Pseudomonas aeruginosa, and Vibrio sp. In addition to lactic acid, L. fermentum secretes antimicrobial proteinacious compound(s) that was found to be active even at neutral pH (pH 7.0). The compound was sensitive to heat treatment and trypsin digestion. Lactobacillus fermentum inhibited the adhesion of enteropathogens to intestinal epithelial cells in vitro. Isolated cell surface associated proteins (SAPs) from L. fermentum were sufficient for the adhesion exclusions of enteropathogenic E. coli. Our results indicate that L. fermentum produces antimicrobial compounds and SAPs to inhibit the growth and adhesion of enteropathogens, respectively.

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Volume75, Issue9

November/December 2010

Pages M546-M551

Lactobacillus Fermentum Isolated from Human Colonic Mucosal Biopsy Inhibits the Growth and Adhesion of Enteric and Foodborne Pathogens

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Lactobacillus Fermentum Isolated from Human Colonic Mucosal Biopsy Inhibits the Growth and Adhesion of Enteric and Foodborne Pathogens

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