Epidermal Growth Factor Immunoreactive Material in the Central Nervous System: Location and Development
Abstract
Epidermal growth factor (EGF) is a potent mitogen with hormonal activity in the gastrointestinal tract. Material cross-reacting with EGF was detected in the central nervous system of the developing and adult albino rat by the indirect immunofluorescence technique. High concentrations of EGF-cross-reacting material were identified in forebrain and midbrain structures of pallidal areas of the brain. These include the globus pallidus, ventral pallidum, entopeduncular nucleus, substantia nigra pars reticulata, and the islands of Calleja. Thus, EGF may represent another gut-brain peptide with potential neurotransmitter-neuromodulator functions in pallidal structures of the extrapyramidal motor systems of the brain.
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Science
Volume 224 | Issue 4653
8 June 1984
8 June 1984
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© 1984.
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Published in print: 8 June 1984
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- James H. Fallon et al.
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Cited by
- Generation of Neurons and Astrocytes from Isolated Cells of the Adult Mammalian Central Nervous System, Science, 255, 5052, (1707-1710), (1992)./doi/10.1126/science.1553558
- Astrocyte Mitogen Inhibitor Related to Epidermal Growth Factor Receptor, Science, 240, 4860, (1784-1786), (1988)./doi/10.1126/science.3289118
- Trophic Stimulation of Cultured Neurons from Neonatal Rat Brain by Epidermal Growth Factor, Science, 238, 4823, (72-75), (1987)./doi/10.1126/science.3498986
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