Soft-Tissue Sarcomas, Breast Cancer, and Other Neoplasms: A Familial Syndrome?
Publication: Annals of Internal Medicine
Volume 71, Number 4
Abstract
Four families were identified in which a pair of children had soft-tissue sarcomas: three sets of sibs and one set of cousins. One parent of each affected child developed cancer; carcinoma of the breast occurred in three mothers under 30 years of age. Other young adults in these families had a high frequency of cancer, with no evidence of underlying genetic disorders known to carry a high risk of neoplasia. The increased familial susceptibility to cancer was manifested not only by the large number of members affected but by a seeming excess of multiple primary neoplasms. These findings suggest a new "familial" syndrome of neoplastic diseases in which heredity or oncogenic agents, or both, may have a causal role.
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Information & Authors
Information
Published In
Annals of Internal Medicine
Volume 71 • Number 4 • 1 October 1969
Pages: 747 - 752
History
Published in issue: 1 October 1969
Published online: 1 December 2008
Keywords
- Adults
- Age groups
- Breast cancer
- Cancer epidemiology
- Cancer genetics
- Cancers and neoplasms
- Children
- Clinical genetics
- Epidemiology
- Genetic diseases
- Genetics
- Hematology and oncology
- Heredity
- Medical genetics
- Obstetrics and gynecology
- Population statistics
- Prevention, policy, and public health
- Research and reporting methods
- Sarcoma
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Soft-Tissue Sarcomas, Breast Cancer, and Other Neoplasms: A Familial Syndrome?. Ann Intern Med.1969;71:747-752. doi:10.7326/0003-4819-71-4-747
Soft-Tissue Sarcomas, Breast Cancer, and Other Neoplasms: A Familial Syndrome?. Ann Intern Med.1969;71:747-752. doi:10.7326/0003-4819-71-4-747
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