Abstract
Oxidative stress has been implicated in numerous pathophysiological conditions and also aging. The tools for studying oxidative stress are now expanding as a result of the human genome effort and, in particular, expanding knowledge on human genetic variation. A few genetic variants, mostly in the form of single nucleotide polymorphisms of relevance to oxidative stress are already studied by a molecular epidemiologic approach. A review of the current knowledge on variant human genes that are directly implicated in human protection against oxidative stress is presented.
Publication types
- Research Support, Non-U.S. Gov't
- Review
MeSH terms
- Animals
- Antioxidants
- Cardiovascular Diseases / genetics
- Genetic Predisposition to Disease*
- Genetic Variation*
- Glutathione / metabolism
- Glutathione Peroxidase / genetics
- Glutathione Peroxidase GPX1
- Glutathione Transferase / genetics
- Humans
- Isoenzymes / genetics
- Mice
- Microsomes / enzymology
- Neoplasms / genetics
- Oxidative Stress / genetics*
- Parkinson Disease / genetics
- Polymorphism, Single Nucleotide / genetics
- Superoxide Dismutase / genetics
Substances
- Antioxidants
- Isoenzymes
- Glutathione Peroxidase
- Superoxide Dismutase
- Glutathione Transferase
- Glutathione
- Glutathione Peroxidase GPX1