Abstract
Use of antioxidant components is a new approach for improvement of insulin resistance (IR) as a main feature of type 2 diabetes and its complications. The aim of this study was to investigate the effects of broccoli sprouts powder (BSP) containing high concentration of sulphoraphane on IR in type 2 diabetic patients. Eighty-one patients were randomly assigned to receive 10 g/d BSP (A, n = 27), 5 g/d BSP (B, n = 29) and placebo (C, n = 25) for 4 weeks. Fasting serum glucose and insulin concentration, glucose to insulin ratio and homoeostasis model assessment of IR (HOMA-IR) index were measured at baseline and again 4 weeks after treatment. Seventy-two patients completed the study and 63 were included in the analysis. After 4 weeks, consumption of 10 g/d BSP resulted in a significant decrease in serum insulin concentration and HOMA-IR (p = 0.05 for treatment effect). Therefore, broccoli sprouts may improve IR in type 2 diabetic patients.
Publication types
- Comparative Study
- Randomized Controlled Trial
- Research Support, Non-U.S. Gov't
MeSH terms
- Adult
- Antioxidants / administration & dosage
- Antioxidants / adverse effects
- Antioxidants / analysis
- Antioxidants / therapeutic use*
- Blood Glucose / analysis
- Brassica / chemistry*
- Diabetes Mellitus, Type 2 / blood
- Diabetes Mellitus, Type 2 / diet therapy*
- Diabetes Mellitus, Type 2 / metabolism
- Dietary Supplements* / adverse effects
- Dietary Supplements* / analysis
- Double-Blind Method
- Female
- Humans
- Hyperglycemia / etiology
- Hyperglycemia / prevention & control
- Hyperinsulinism / etiology
- Hyperinsulinism / prevention & control
- Insulin / blood
- Insulin Resistance*
- Iran
- Isothiocyanates / administration & dosage
- Isothiocyanates / adverse effects
- Isothiocyanates / analysis
- Isothiocyanates / therapeutic use
- Male
- Middle Aged
- Patient Compliance
- Patient Dropouts
- Plant Shoots / chemistry*
- Sulfoxides
Substances
- Antioxidants
- Blood Glucose
- Insulin
- Isothiocyanates
- Sulfoxides
- sulforaphane