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Perspective

The Future of Genetic Studies of Complex Human Diseases

Science
13 Sep 1996
Vol 273, Issue 5281
pp. 1516-1517

Abstract

The identification of the genetic basis of complex human diseases such as schizophrenia and diabetes has proven difficult. In their Perspective, Risch and Merikangas propose that we can best accomplish this goal by combining the power of the human genome project with association studies, a method for determining the basis of a genetic disease.

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References

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LANDER E.S., GENETIC DISSECTION OF COMPLEX TRAITS, SCIENCE 265, 2037 (1994).
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RISCH N, ASSESSING THE ROLE OF HLA-LINKED AND UNLINKED DETERMINANTS OF DISEASE, AMERICAN JOURNAL OF HUMAN GENETICS 40, 1 (1987).
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RISCH N, LINKAGE STRATEGIES FOR GENETICALLY COMPLEX TRAITS .2. THE POWER OF AFFECTED RELATIVE PAIRS, AMERICAN JOURNAL OF HUMAN GENETICS 46, 229 (1990).
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SPIELMAN R.S., TRANSMISSION TEST FOR LINKAGE DISEQUILIBRIUM - THE INSULIN GENE REGION AND INSULIN-DEPENDENT DIABETES-MELLITUS (IDDM), AMERICAN JOURNAL OF HUMAN GENETICS 52, 506 (1993).

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Published In

Science
Volume 273 | Issue 5281
13 September 1996

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Published in print: 13 September 1996

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Authors

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Neil Risch [email protected]
N. Risch is in the Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305-5120, USA. E-mail: [email protected].
Kathleen Merikangas [email protected]
K. Merikangas is in the Departments of Epidemiology and Psychiatry Unit, Yale University School of Medicine, New Haven, CT 06510, USA. E-mail: [email protected]

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