Requirements for Nitric Oxide Generation from Isoniazid Activation In Vitro and Inhibition of Mycobacterial Respiration In Vivo
ABSTRACT
MATERIALS AND METHODS
In vitro spin trapping of INH-derived NO˙.
In vitro spin trapping of oxygen and carbon-centered INH-derived free radicals.
Aconitase and cytochrome c oxidase activities upon exposure to INH.
Isocitrate dehydrogenase assay.
RESULTS AND DISCUSSION
Generation of NO˙ from INH depends on KatG and H2O2.
Initial investigations of the potential pathway of NO˙ production from INH.
Biological activity of NO˙ generated during INH-derived NO˙ activation.
Conclusions.
Acknowledgments
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