Treatment of seizures with medroxyprogesterone acetate
Preliminary report
Abstract
Medroxyprogesterone acetate (MPA), a synthetic progesterone, was added to the antiepileptic drug regimen of 14 women who had uncontrolled seizures. Of the 11 women who developed amenorrhea, 7 reported fewer seizures during MPA therapy. Overall reductions in seizure frequency averaged 30% (n = 11), declining from a baseline 8.3 ± 5.8 seizures per month to 5.1 ± 4.1 seizures per month (p = 0.02). No serious side effects were encountered, but spotting was common. These preliminary data suggest further evaluation of MPA for catamenial seizures.
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© 1984 by the American Academy of Neurology.
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Published online: September 1, 1984
Published in print: September 1984
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