Abstract
A mouse Mix-like gene, Mml, related to the Xenopus Mix/Bix homeobox gene family and the chick CMIX gene has been identified. At E5.5, Mml is expressed symmetrically in the visceral endoderm but by E6.0 this expression is noticeably asymmetric. At E6.5, expression is restricted to the nascent primitive streak. Mml expression persists in the primitive streak through E7.5-E9.5, marking those cells fated to form extra-embryonic and lateral mesoderm.
Publication types
- Research Support, Non-U.S. Gov't
MeSH terms
- Amino Acid Sequence
- Animals
- Avian Proteins*
- Endoderm / metabolism
- Gastrula / metabolism*
- Gene Expression*
- Homeodomain Proteins / genetics
- Homeodomain Proteins / metabolism*
- Mesoderm / metabolism
- Mice
- Molecular Sequence Data
- Phylogeny
- Sequence Homology, Amino Acid
- Time Factors
- Xenopus Proteins*
Substances
- Avian Proteins
- CMIX protein, chicken
- Homeodomain Proteins
- Mix1 protein, Xenopus
- Mixl1 protein, mouse
- Xenopus Proteins