Polyclonal expansion of TCR Vβ 21.3+ CD4+ and CD8+ T cells is a hallmark of multisystem inflammatory syndrome in children
MIS-C’s unique TCR repertoire
Abstract
INTRODUCTION
RESULTS
MIS-C presentation overlapped with TSS and KD
High levels of proinflammatory cytokines in MIS-C contrasted with lymphopenia and low HLA-DR expression in monocytes
Expansion of Vβ21.3+ peripheral T cells in a large fraction of patients with MIS-C
TCR sequencing highlighted the polyclonal nature of TCR Vβ21.3 expansions
Vβ21.3+ T cells had an activated phenotype but did not react against SARS-CoV-2 peptides
DISCUSSION
MATERIALS AND METHODS
Study design and human subjects
Immunological analyses
Cytokines and IFN score assessment
T cell Vβ repertoire analysis and immunophenotyping
TCR sequencing and analysis
Stimulation with SARS-CoV-2 overlapping peptide pools and flow cytometry
Serology
Statistical analyses
Acknowledgments
Supplementary Material
Summary
Resources
REFERENCES AND NOTES
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May 2021
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- Marion Moreews et al.
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- Immunology of Multisystem Inflammatory Syndrome after COVID-19 in Children: A Review of the Current Evidence, International Journal of Molecular Sciences, 24, 6, (5711), (2023).https://doi.org/10.3390/ijms24065711
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- Severe COVID-19 versus multisystem inflammatory syndrome: comparing two critical outcomes of SARS-CoV-2 infection , European Respiratory Review, 32, 167, (220197), (2023).https://doi.org/10.1183/16000617.0197-2022
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