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Review Article
Open Access
Engineered Compounds to Control Ice Nucleation and Recrystallization
- Nishaka William1, Sophia Mangan2, Rob N. Ben2, and Jason P. Acker1,3
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View Affiliations Hide AffiliationsAffiliations: 1Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada; email: [email protected] 2Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada 3Innovation and Portfolio Management, Canadian Blood Services, Edmonton, Alberta, Canada
- Vol. 25:333-362 (Volume publication date June 2023) https://doi.org/10.1146/annurev-bioeng-082222-015243
- First published as a Review in Advance on April 27, 2023
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Copyright © 2023 by the author(s).This work is licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See credit lines of images or other third-party material in this article for license information
Abstract
One of the greatest concerns in the subzero storage of cells, tissues, and organs is the ability to control the nucleation or recrystallization of ice. In nature, evidence of these processes, which aid in sustaining internal temperatures below the physiologic freezing point for extended periods of time, is apparent in freeze-avoidant and freeze-tolerant organisms. After decades of studying these proteins, we now have easily accessible compounds and materials capable of recapitulating the mechanisms seen in nature for biopreser-vation applications. The output from this burgeoning area of research can interact synergistically with other novel developments in the field of cryobiology, making it an opportune time for a review on this topic.
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