Abstract
The authors used a liquid-phase radiobinding assay to measure serum anti-myelin oligodendrocyte protein (MOG) immunoglobulin (Ig) G in 87 patients with multiple sclerosis (MS), in 12 patients with encephalomyelitis, and in 47 healthy subjects. Anti-MOG IgM was determined in samples obtained at onset from 40 of 87 patients with MS and in control subjects. The frequency of positive samples with low titers of anti-MOG IgG (< or =5.7%) and IgM (< or =8.3%) was similar in all the groups and subgroups. Binding competition experiments showed that these antibodies had low affinity. Anti-MOG antibodies are not disease specific.
MeSH terms
- Adolescent
- Adult
- Animals
- Autoantibodies / blood
- Autoantibodies / immunology*
- Autoantigens / immunology*
- Demyelinating Diseases / blood
- Demyelinating Diseases / immunology
- Encephalomyelitis / blood
- Encephalomyelitis / immunology
- Encephalomyelitis, Autoimmune, Experimental / blood
- Encephalomyelitis, Autoimmune, Experimental / immunology
- Female
- Humans
- Immunoglobulin G / blood
- Immunoglobulin G / immunology*
- Immunoglobulin M / blood
- Immunoglobulin M / immunology*
- Male
- Mice
- Mice, Inbred C57BL
- Middle Aged
- Multiple Sclerosis, Chronic Progressive / blood
- Multiple Sclerosis, Chronic Progressive / immunology*
- Multiple Sclerosis, Relapsing-Remitting / blood
- Multiple Sclerosis, Relapsing-Remitting / immunology*
- Myelin Proteins
- Myelin-Associated Glycoprotein / immunology*
- Myelin-Oligodendrocyte Glycoprotein
- Rabbits
- Radioligand Assay
- Subacute Sclerosing Panencephalitis / blood
- Subacute Sclerosing Panencephalitis / immunology
Substances
- Autoantibodies
- Autoantigens
- Immunoglobulin G
- Immunoglobulin M
- MOG protein, human
- Mog protein, mouse
- Myelin Proteins
- Myelin-Associated Glycoprotein
- Myelin-Oligodendrocyte Glycoprotein