Abstract
Oligonucleotide probes were used to investigate the role of DQ beta molecules in susceptibility to multiple sclerosis. Although shared amino acid and nucleotide sequences in DQ beta 1 have been suggested to be critical in disease development, we find that the distribution of sequences corresponding to residues 71-77 is not greater in patients versus controls.
MeSH terms
- Alleles*
- Base Sequence
- HLA-DQ Antigens / analysis
- HLA-DQ Antigens / genetics*
- HLA-DQ beta-Chains
- HLA-DR Antigens / analysis
- HLA-DR Antigens / genetics
- Humans
- Molecular Sequence Data
- Multiple Sclerosis / genetics
- Multiple Sclerosis / immunology*
- Oligonucleotide Probes
Substances
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DQbeta antigen
- HLA-DR Antigens
- Oligonucleotide Probes