Abstract
When considering the hierarchical organization of pathological signaling cascades in immunological disorders of the brain, certain cytokines might be considered pinnacles of pathophysiological importance, with their presence determining the appearance or the course of a particular disease. Interleukin-1 (IL-1), IL-6, IL-17, and tumor necrosis factor are critical for the pathogenesis of inflammation in specific brain disorders. Targeting these cytokines or their receptors can alter the course of several neurological diseases, but the effects may be beneficial or harmful.
MeSH terms
- Brain Diseases / immunology*
- Brain Diseases / metabolism
- Brain Diseases / pathology
- Cytokines / immunology*
- Cytokines / metabolism
- Humans
- Inflammation / immunology*
- Inflammation / metabolism
- Inflammation / pathology
- Inflammation Mediators / immunology*
- Inflammation Mediators / metabolism
- Interleukin-1 / immunology
- Interleukin-1 / metabolism
- Interleukin-17 / immunology
- Interleukin-17 / metabolism
- Interleukin-6 / immunology
- Interleukin-6 / metabolism
- Models, Immunological
- Signal Transduction / immunology*
- Tumor Necrosis Factor-alpha / immunology
- Tumor Necrosis Factor-alpha / metabolism
Substances
- Cytokines
- Inflammation Mediators
- Interleukin-1
- Interleukin-17
- Interleukin-6
- Tumor Necrosis Factor-alpha