Role of metabolism in cancer cell radioresistance and radiosensitization methods

Le Tang; Fang Wei; Yingfen Wu; Yi He; Lei Shi; Fang Xiong; Zhaojian Gong; Can Guo; Xiayu Li; Hao Deng; Ke Cao; Ming Zhou; Bo Xiang; Xiaoling Li; Yong Li; Guiyuan Li; Wei Xiong; Zhaoyang Zeng

doi:10.1186/s13046-018-0758-7

Role of metabolism in cancer cell radioresistance and radiosensitization methods

J Exp Clin Cancer Res. 2018 Apr 23;37(1):87. doi: 10.1186/s13046-018-0758-7.

Authors

Le Tang^{1 2 3}, Fang Wei^{1 2}, Yingfen Wu², Yi He^{2 4}, Lei Shi², Fang Xiong¹, Zhaojian Gong², Can Guo², Xiayu Li^{2 3}, Hao Deng³, Ke Cao³, Ming Zhou^{1 2 3}, Bo Xiang^{1 2 3}, Xiaoling Li^{1 2 3}, Yong Li^{2 5}, Guiyuan Li^{1 2 3}, Wei Xiong^{6 7 8}, Zhaoyang Zeng^{9 10 11}

Affiliations

¹ The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, China.
² The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China.
³ Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁴ Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
⁵ Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
⁶ The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, China. xiongwei@csu.edu.cn.
⁷ The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China. xiongwei@csu.edu.cn.
⁸ Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. xiongwei@csu.edu.cn.
⁹ The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, China. zengzhaoyang@csu.edu.cn.
¹⁰ The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China. zengzhaoyang@csu.edu.cn.
¹¹ Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. zengzhaoyang@csu.edu.cn.

Abstract

Background: Radioresistance is a major factor leading to the failure of radiotherapy and poor prognosis in tumor patients. Following the application of radiotherapy, the activity of various metabolic pathways considerably changes, which may result in the development of resistance to radiation.

Main body: Here, we discussed the relationships between radioresistance and mitochondrial and glucose metabolic pathways, aiming to elucidate the interplay between the tumor cell metabolism and radiotherapy resistance. In this review, we additionally summarized the potential therapeutic targets in the metabolic pathways.

Short conclusion: The aim of this review was to provide a theoretical basis and relevant references, which may lead to the improvement of the sensitivity of radiotherapy and prolong the survival of cancer patients.

Keywords: Cancer; Metabolic pathway; Radioresistance; Radiotherapy; Sensitivity.

Publication types

Review

MeSH terms

Humans
Neoplasms / pathology
Neoplasms / radiotherapy*
Radiation Tolerance / immunology*
Radiation-Sensitizing Agents / pharmacology
Radiation-Sensitizing Agents / therapeutic use*

Substances

Radiation-Sensitizing Agents

Abstract

Publication types

MeSH terms

Substances

Grants and funding