Review
An update on vitamin D signaling and cancer
Under a Creative Commons license
open access
Abbreviations
1,25(OH)2D3
1α,25-dihydroxyvitamin D3, also called calcitriol
25(OH)D3
25-hydroxyvitamin D3, also called calcidiol
AML
acute myeloid leukemia
AMPK
adenosine monophosphate-activated protein kinase (official gene symbol: PRKAA1)
APC
APC regulator of WNT signaling pathway
AXIN2
axin 2
BCL2
BCL2 apoptosis regulator
BRCA1
BRCA1 DNA repair associated
BRD7
bromodomain containing 7
CAF
cancer-associated fibroblast
CCND1
cyclin D1
CDH
cadherin
CDK
cyclin dependent kinase
CDKN
cyclin dependent kinase inhibitor
CEBPA
CCAAT/enhancer binding protein alpha
ChIP-seq
chromatin immunoprecipitation sequencing
CRC
colorectal cancer
CST5
cystatin D
CTCF
CCCTC-binding factor
CTNNB1
catenin beta 1
CXCL8
C-X-C motif chemokine ligand 8, also called IL8
CYP24A1
cytochrome P450 family 24 subfamily A member 1
DKK1
Dickkopf WNT signaling pathway inhibitor 1
EGF
epidermal growth factor
EGFR
epidermal growth factor receptor
ER
estrogen receptor (official gene symbols: ESR1 and ESR2)
FOS
Fos proto-oncogene, AP-1 transcription factor subunit
GABPA
GA binding protein transcription factor subunit alpha
HER2
human epidermal growth factor receptor 2 (official gene symbol: ERBB2)
HOXA9
homeobox A9
ID1
inhibitor of DNA binding 1, HLH protein
IFNG
interferon gamma
IGF
insulin-like growth factor
IL
interleukin
JAK
Janus kinase
JUN
Jun proto-oncogene, AP-1 transcription factor subunit
KDM6B
lysine demethylase 6B
LGR5
leucine rich repeat containing G protein-coupled receptor 5
MAPK14
mitogen-activated protein kinase 14
MECOM
MDS1 and EVI1 complex locus
MEIS1
meis homeobox 1
miR
microRNA
MMP9
matrix metalloprotease 9
MYC
MYC proto-oncogene, BHLH transcription factor
ncRNA
non-coding RNA
NF
normal fibroblast
PBMC
peripheral blood mononuclear cell
Pol II
RNA polymerase II
PR
progesterone receptor (official gene symbol: PGR)
PU.1
purine-rich box 1, Spi-1 proto-oncogene (official gene symbol: SPI1)
PTGER2
prostaglandin E receptor 2
PTGS2
prostaglandin-endoperoxide synthase 2, also called COX2
PTH
parathyroid hormone
RHOA
Ras homolog family member A
RNA-seq
RNA sequencing
RNF43
ring finger protein 43
ROCK1
Rho associated coiled-coil containing protein kinase 1
RPS6KA5
ribosomal protein S6 kinase A5, also called MSK1
RSPO2
R-spondin 2
RXR
retinoid X receptor
SERPINE1
serpin family E member 1, also called plasminogen activator inhibitor (PAI)
SNAI
snail family transcriptional repressor
SPRY2
sprouty RTK signaling antagonist 2
STAT
signal transducers and activators of transcription
TAD
topologically associated domain
TCF7L2
transcription factor 7 like 2
TGFBR1
transforming growth factor beta receptor 1
TH
T helper
TIMP1
TIMP metallopeptidase inhibitor 1
TLR
Toll-like receptor
TNBC
triple-negative breast cancer
TNF
tumor necrosis factor
TNC
tenascin C
Treg
regulatory T
TSS
transcription start site
VDR
vitamin D receptor
VEGFA
vascular endothelial growth factor A
WNT3A
WNT family member 3A
Keywords
Vitamin D
Calcitriol
Vitamin D signaling
VDR
Vitamin D target genes
Chromatin
Epigenome
Immune system
Colon cancer
Prostate cancer
Breast cancer
Hematological malignancies
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© 2020 The Author(s). Published by Elsevier Ltd.