Evidence from a large-scale meta-analysis indicates eczema reduces the incidence of glioma

Oncotarget. 2016 Sep 20;7(38):62598-62606. doi: 10.18632/oncotarget.11545.

Abstract

We investigated the relationship between eczema and the risk of primary glioma. Relevant studies were selected through electronic searches of PubMed and EMBASE. A meta-analysis of 12 case-control studies and one cohort study was performed. A fixed effect model was applied to analyze 13 studies consisting of 10,897 glioma cases and 56,081 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the strength of the associations. The data demonstrate that eczema significantly reduces the risk of glioma (OR = 0.69, 95% CI = 0.61-0.78, P < 0.001). Additional studies with larger patient cohorts are required to validate our findings.

Keywords: eczema; glioma; meta-analysis.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Brain Neoplasms / complications*
  • Brain Neoplasms / prevention & control*
  • Case-Control Studies
  • Cohort Studies
  • Eczema / complications*
  • Eczema / physiopathology*
  • Glioma / complications*
  • Glioma / prevention & control*
  • Humans
  • Odds Ratio
  • Risk Factors