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Accepted manuscript

The role of vitamin D in outcomes of critical care in COVID-19 patients: Evidence from an umbrella meta-analysis of interventional and observational studies

Published online by Cambridge University Press:  24 April 2024

Abdolreza Jamilian ,
Faezeh Ghalichi ,
Fatemeh Hamedi Kalajahi ,
Nima Radkhah Open the ORCID record for Nima Radkhah [Opens in a new window] ,
Neda Jourabchi ,
Vali Musazadeh ,
Ehsan Amini-Salehi ,
Meysam Zarezadeh  and
Alireza Ostadrahimi
Abdolreza Jamilian
Affiliation:
City of London Dental School, University of Bolton, London, UK Orthodontic Department, Dental School, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Faezeh Ghalichi
Affiliation:
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
Fatemeh Hamedi Kalajahi
Affiliation:
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
Nima Radkhah
Affiliation:
Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
Neda Jourabchi
Affiliation:
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
Vali Musazadeh
Affiliation:
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
Ehsan Amini-Salehi
Affiliation:
School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Meysam Zarezadeh*
Affiliation:
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
Alireza Ostadrahimi*
Affiliation:
Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
*
**Meysam Zarezadeh, Ph.D. of Nutritional Sciences, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Address: Attar-Neishaburi St., Golgasht Alley, Azadi Blvd., Tabriz, Iran., Fax Number: +984133340634, Phone Number: +989143319531, Email: Meysam.za93@gmail.com, zarezadehm@tbzmed.ac.ir
*Alireza Ostadrahimi, Professor of Clinical Nutrition, School of Nutrition and Food Sciences, Address: Attar-Neishaburi St., Golgasht Alley, Azadi Blvd., Tabriz, Iran., Fax Number: +984133340634, Phone Number: +989143135845, Email: ostadrahimi@tbzmed.ac.ir
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Abstract

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Objectives:

Several meta-analyses have suggested the beneficial effect of vitamin D on patients infected with SARS-CoV-2. This umbrella meta-analysis aims to evaluate influence of vitamin D supplementation on clinical outcomes and the mortality rate of COVID-19 patients.

Design:

Present study was designed as an umbrella meta-analysis. The following international databases were systematically searched till March 2023: Web of Science, PubMed, Scopus, and Embase.

Settings:

Random-effects model was employed to perform meta-analysis. Using AMSTAR critical evaluation tools, the methodological quality of the included meta-analyses was evaluated.

Participants:

Adult patients suffering from COVID-19 were studied.

Results:

Overall, 13 meta-analyses summarizing data from 4 RCTs and 9 observational studies were identified in this umbrella review. Our findings revealed that vitamin D supplementation and status significantly reduced mortality of COVID-19 [Interventional studies: (ES= 0.42; 95% CI: 0.10, 0.75, p <0.001; I2 = 20.4%, p=0.285) and observational studies (ES= 1.99; 95% CI: 1.37, 2.62, p <0.001; I2 = 00.0%, p=0.944). Also, vitamin D deficiency increased risk of infection and disease severity among patients.

Conclusion:

Overall, vitamin D status is a critical factor influencing the mortality rate, disease severity, admission to ICU and being detached from mechanical ventilation. It is vital to monitor the vitamin D status in all patients with critical conditions including COVID patients.

Keywords

Vitamin DMortalityIntensive care unitCritical illnessCOVID-19Umbrella meta-analysis
Type
Systematic Review and Meta-Analysis
Information
Public Health Nutrition , Accepted manuscript , pp. 1 - 25
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
Copyright
© The Authors 2024