Hepatoprotective Activity of Moringa oleifera on Antitubercular Drug-Induced Liver Damage in Rats
Publication: Journal of Medicinal Food
Volume 5, Issue Number 3
Abstract
Moringa oleifera Lam (Moringaceae), commonly known as "Drumstick," is used in Indian folk medicine for the treatment of various illness. We have evaluated the hepatoprotective effect of an ethanolic extract of M. oleifera leaves on liver damage induced by antitubercular drugs such as isoniazid (INH), rifampicin (RMP), and pyrazinamide (PZA) in rats. Oral administration of the extract showed a significant protective action made evident by its effect on the levels of glutamic oxaloacetic transaminase (aspartate aminotransferase), glutamic pyruvic transaminase (alanine aminotransferase), alkaline phosphatase, and bilirubin in the serum; lipids, and lipid peroxidation levels in liver. This observation was supplemented by histopathological examination of liver sections. The results of this study showed that treatment with M. oleifera extracts or silymarin (as a reference) appears to enhance the recovery from hepatic damage induced by antitubercular drugs.
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Published In
Journal of Medicinal Food
Volume 5 • Issue Number 3 • September 2002
Pages: 171 - 177
PubMed: 12495589
History
Published online: 7 July 2004
Published in print: September 2002
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