Current Issue
- April 23, 2024
- vol. 121
- no. 17
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Sudden cardiac death (SCD) is a major public health issue. Inherited arrhythmias account for a large portion of SCDs in adolescents. We established a mouse pedigree that exhibits severe inherited arrhythmias with SCD after ...Inherited arrhythmia syndromes (IASs) can cause life-threatening arrhythmias and are responsible for a significant proportion of sudden cardiac deaths (SCDs). Despite progress in the development of devices to prevent SCDs, the precise molecular mechanisms ...
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Brain-derived neurotrophic factor (BDNF) plays a critical role in modulating synaptic physiology and contributes to the fundamental pathophysiology of neuropsychiatric disorders. Yet its function at the presynaptic terminal remains poorly ...Brain-derived neurotrophic factor (BDNF) plays a critical role in synaptic physiology, as well as mechanisms underlying various neuropsychiatric diseases and their treatment. Despite its clear physiological role and disease relevance, BDNF’s function at ...
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Emotions coordinate our behavior and physiological states during survival-salient events and pleasurable interactions. Even though we are often consciously aware of our current emotional state, such as anger or happiness, the mechanisms giving ...Emotions are often felt in the body, and somatosensory feedback has been proposed to trigger conscious emotional experiences. Here we reveal maps of bodily sensations associated with different emotions using a unique topographical self-report method. In ...
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Respiratory virus infections in humans are a significant global health concern, causing a wide range of diseases with substantial morbidity and mortality worldwide. This underscores the urgent need for effective interventions to reduce the ...Respiratory virus infections in humans cause a broad-spectrum of diseases that result in substantial morbidity and mortality annually worldwide. To reduce the global burden of respiratory viral diseases, preventative and therapeutic interventions that are ...
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We introduce a model of collective behavior, proposing that individual members within a group, such as a school of fish or a flock of birds, act to minimize surprise. This active inference approach naturally generates well-known collective ... Collective motion is ubiquitous in nature; groups of animals, such as fish, birds, and ungulates appear to move as a whole, exhibiting a rich behavioral repertoire that ranges from directed movement to milling to disordered swarming. Typically, such ...
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