Review Article
Negative Regulators of Brown Adipose Tissue (BAT)-Mediated Thermogenesis
Bal Krishan Sharma,
Mallikarjun Patil,
Ande Satyanarayana,
Bal Krishan Sharma
Department of Biochemistry and Molecular Biology, Molecular Oncology and Biomarkers Program, Georgia Regents University Cancer Center, Georgia Regents University, Augusta, Georgia
Search for more papers by this authorMallikarjun Patil
Department of Biochemistry and Molecular Biology, Molecular Oncology and Biomarkers Program, Georgia Regents University Cancer Center, Georgia Regents University, Augusta, Georgia
Search for more papers by this authorCorresponding Author
Ande Satyanarayana
Department of Biochemistry and Molecular Biology, Molecular Oncology and Biomarkers Program, Georgia Regents University Cancer Center, Georgia Regents University, Augusta, Georgia
Correspondence to: Ande Satyanarayana, Department of Biochemistry and Molecular Biology, Molecular Oncology and Biomarkers Program, Georgia Regents University Cancer Center, Georgia Regents University, Room-CN3150, 1410 Laney Walker Blvd., Augusta, 30912 GA.
E-mail: [email protected]
Search for more papers by this author
Bal Krishan Sharma,
Mallikarjun Patil,
Ande Satyanarayana,
Bal Krishan Sharma
Department of Biochemistry and Molecular Biology, Molecular Oncology and Biomarkers Program, Georgia Regents University Cancer Center, Georgia Regents University, Augusta, Georgia
Search for more papers by this authorMallikarjun Patil
Department of Biochemistry and Molecular Biology, Molecular Oncology and Biomarkers Program, Georgia Regents University Cancer Center, Georgia Regents University, Augusta, Georgia
Search for more papers by this authorCorresponding Author
Ande Satyanarayana
Department of Biochemistry and Molecular Biology, Molecular Oncology and Biomarkers Program, Georgia Regents University Cancer Center, Georgia Regents University, Augusta, Georgia
Correspondence to: Ande Satyanarayana, Department of Biochemistry and Molecular Biology, Molecular Oncology and Biomarkers Program, Georgia Regents University Cancer Center, Georgia Regents University, Room-CN3150, 1410 Laney Walker Blvd., Augusta, 30912 GA.
E-mail: [email protected]
Search for more papers by this author
The authors declare no competing financial conflicts of interest.
Abstract
Brown adipose tissue (BAT) is specialized for energy expenditure, a process called adaptive thermogenesis. PET-CT scans recently demonstrated the existence of metabolically active BAT in adult humans, which revitalized our interest in BAT. Increasing the amount and/or activity of BAT holds tremendous promise for the treatment of obesity and its associated diseases. PGC1α is the master regulator of UCP1-mediated thermogenesis in BAT. A number of proteins have been identified to influence thermogenesis either positively or negatively through regulating the expression or transcriptional activity of PGC1α. Therefore, BAT activation can be achieved by either inducing the expression of positive regulators of PGC1α or by inhibiting the repressors of the PGC1α/UCP1 pathway. Here, we review the most important negative regulators of PGC1α/UCP1 signaling and their mechanism of action in BAT-mediated thermogenesis. J. Cell. Physiol. 229: 1901–1907, 2014. © 2014 Wiley Periodicals, Inc.
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