Riassunto
Vengono descritti 6 pazienti con iperlipemia da carboidrati, diabete non chetonurico e obesità di medio grado.
Il trattamento con una dieta ipocalorica a basso contenuto in carboidrati ha comportato diminuzione del peso corporeo e normalizzazione o spiccata riduzione della glicemia a digiuno e della trigliceridemia.
Viene discussa la stretta relazione tra utilizzazione dei carboidrati e le anomalie metaboliche osservate.
Resume
On observe 6 cas de malades avec hyperlipémie due aux carbohydrates, diabète non cétogénique et obésité de degré moyen.
Le traitement avec une alimentation hypocalorique pauvre en carbohydrates a porté à une diminution pondérale et à une normalisation ou à une forte réduction de la glycémie à jeun et de la triglycéridémie.
On discute l'étroit rapport entre utilisation des carbohydrates et les anomalies métaboliques observées.
Resumen
Se describen 6 pacientes con hiperlipemia por carbohidratos, diabetes no quetonúrica y obesidad de mediana gravedad.
El tratamiento con una dieta hipocalórica de bajo contenido en carbohidratos produjo una disminución del peso corporal y la normalización o notable reducción de la glicemia en ayunas y de la trigliceridemia.
Se discute la íntima relación que existe entre la utilización de los carbohidratos y las anomalías metabólicas observadas.
Zusammenfassung
Es werden 6 Patienten mit Kohlehydrat-Hyperlipaemie, Diabetes ohne Ketonurie und mittelmaessiger Fettleibigkeit beschrieben.
Die Behandlung mit einer hypokalorischen Diaet, mit niedrigem Gehalt an Kohlenhydraten, bewirkte Verminderung des Koerpergewichtes sowie Normalisierung oder ausgepraegte Herabsetzung des Nuechternblutzuckers und der Triglyzeridaemie.
Es werden die engen Beziehungen zwischen Kohlenhydrat-Verwertung und den beobachteten metabolischen Anomalien diskutiert.
Summary
Six patients are described presenting carbohydrate-induced hyperlipemia, stable non-ketonuric diabetes and mild obesity.
Treatment with hypocaloric low carbohydrate diet induced a decrease of body weight, normalization or marked decrease of fasting blood sugar and serum triglycerides.
The strict relationship between carbohydrate intake and the observed metabolic abnormalities is discussed.
Bibliografia
Adlersberg D., Wang C.: Syndrome of Idiopathic Hyperlipemia, Mild Diabetes Mellitus and Severe Vascular Damage - Diabetes4 210, 1955.
Ahrens E. H., Hirsch J., Oette K., Farquhar J. W., Stein Y.: Carbohydrate-Induced and Fat-Induced Lipemia - Tr. A. Am. Physicians74 134, 1961.
Albrink M. J., Davidson P. C.: Impaired Glucose Tolerance in Patients with Hypertriglyceridemia- J. Lab. clin. Med.4 573, 1964.
Albrink M. J., Lavietes P. H., Man E. B.: Vascular Disease and Serum Lipids in Diabetes Mellitus. Observations Over Thirthy Years (1931–1961) - Ann. intern. Med.58 305, 1963.
Albrink M. J., Man E. B.: Serum Triglycerides in Health and Diabetes -Diabetes7 194, 1958.
Albrink M. J., Meigs J. W.: Interrelationship between Skinfold Thickness, Serum Lipids and Blood Sugar in Normal Men - Amer. J. clin. Nutr.15 255, 1964.
Albrink M. J., Meigs J. W., Granoff M. A.: Weight Gain and Serum Triglycerides in Normal Men - New Engl. J. Med.266 484, 1962.
Antoniades N. H., Bougas J. A., Camerini-Davalos R., Pyle H. M.: Insulin Regulatory Mechanism and Diabetes Mellitus - Diabetes13 230, 1964.
Avogaro P., Crepaldi G., Zeni G., Beatrice L.: Aspetti del metabolismo lipidico nell'obesità essenziale. Il comportamento dei lipidi sierici - Acta med. patav.22 227, 1962.
Benard H., Dunet R., Gajdos A., Pequinot H., Polonowsky J.: Hyperlipemie essentielle -Sem. Hôp. Paris31 3077, 1955.
Bloor W. R.: The Determination of Cholesterol in Blood - J. biol. Chem.24 227, 1916.
Boulet P., Lirouze J., Arnavielhe M., Bonny etSchmouker: Hyperlipémie xanthomateuse plethorique. Efficacité spectaculaire de l'hormone de croissance - Bull. Soc. Méd. Paris73 453, 1957.
Bürnstein M., Samaille J.: Dosage des Beta-Lipoproteines seriques après precipitation sélective par l'heparine - Presse méd.66 974, 1958.
Carteaud A., Mamon H.: Sur les deux cas de xanthomatoses. Hyperlipémie essentielle et xanthomatose familiale; action de l'heparine local - Sem. Hôp. Paris26 1501, 1956.
Carton F. K.: Hyperlipemie de l'adulte paraissant essentielle - Soc. Franc. Dermath. Paris, July 1958.
Crepaldi G., Avogaro P., Enzi G., Tiengo A.: La terapia dell'iperlipemia essenziale - Settim. Osp.7 528, 1965.
Davidson P., Albrink M. J.: Abnormal Plasma Insulin Response with High Plasma Triglycerides Independent of Clinical Diabetes or Obesity - J. clin. Invest.45 1000, 1966.
Dole V. P.: Relation between Non-Esterified Fatty Acids in Plasma and Metabolism of Glucose- J. clin. Invest.35 150, 1956.
Fredrickson D. S., Lees R. S.: Familial Hyperlipoproteinemia. In:Stanbury J. B., Wyngaarden J. B., Fredrickson D. S.: The Metabolic Basis of Inherited Disease - Mc Graw-Hill, New York, 1966, pag. 429.
Fredrickson D. S., Ono L., Davis L.: Lipolytic Activity of Post-Heparin Plasma in Hyperglyceridemia- J. Lipid Res.4 24, 1963.
Gordon R. S.: Relationship between Obesity and Diabetes - Metabolism11 819, 1962.
Hagedorn H. C., Jensen B. N.: Zur Mikrobestimmung des Blutzuckers mittels Ferricyanid -Biochem. Z.135 46, 1935.
Hales C. N.: Plasma Insulin in Diabetes. In:Cameron M. P., O'Connor M.: The Aetiology of Diabetes Mellitus and its Complications - Ciba Foundation, Colloquia on Endocrinology, Vol.15, J. A. Churchill, London 1964, pag. 140.
Harris L. V. D., Van Eck W. F., Man E. B., Peters J. B.: Serum Lipids in Diabetic Acidosis -Metabolism2 120, 1953.
Kane J. P., Longscope C., Pavlatos F. G., Grodsky G. M.: Studies of Carbohydrates Metabolism in Idiophatic Hypertriglyceridemia - Metabolism14 417, 1965.
Karam J. H., Grodsky G. M., Pavlatos F. C., Forsham P. H.: Critical Factors in Excessive Serum Insulin Response to Glucose: Obesity in Maturity-Onset Diabetes and Growth Hormone in Acromegaly - Lancet1 286, 1965.
Kennedy E. P.: The Enzymatic Synthesis of Phospholipids and Triglycerides. In:Page I. H.: Chemistry of Lipides as Related to Atherosclerosis - Ch. C. Thomas Springfield, Ill. 1958, pag. 325.
Knittle J. L., Ahrens E. H.: Carbohydrate Metabolism in two Forms of Hyperglyceridemia- J. clin. Invest43 485, 1964.
Langdon R. G.: The Biosynthesis of Fatty Acids in Cell-Free Preparation of Mammalian Liver. InPage I. H.: Chemistry of Lipids as Related to Atherosclerosis - Ch. C. Thomas, Springfield, Ill. 1958, pag. 291.
Man E. B., Peters J. P.: Lipids of Serum in Diabetic Acidosis - J. clin. Invest.13 237, 1934.
Man E. B., Peters J. P.: Serum Lipids in Diabetes - J. clin. Invest.14 579, 1935.
Movitt E. R., Gerstl B., Sherwood F., Epstein C. G.: Essential Hyperlipemia - Arch. intern. Med.87 79, 1951.
Pavel I.: Prevenzione delle complicazioni diabetiche con la profilassi del diabete-malattia -Atti 1° Simp. Intern. sul diabete, Modena 21–22 settembre 1963 - Clin. ter.30 263, 1964.
Randle P. M., Garland P. B., Hales C. N., Newsholme E. A.: The Glucose-Fatty Acid Cycle. Its Role in Insulin Sensitivity and the Metabolic Disturbances of Diabetes Mellitus - Lancet1 785, 1963.
Reaven G. M., Farquhar J. M.: Relationship between Plasma Triglycerides, Glucose and Insulin Concentration in Patients with Carbohydrate-Induced Lipemia - Program of 48th Meeting of the Endocrine Society, Chicago, June 20–22, 1956.
Sanbar S. S., Zweifler A. J., Conway F. J.: Carbohydrate Metabolism in Essential Hyperlipemia- Circulation30 (Suppl. 3), 27, 1964.
Sigstad H.: A Family with Mild Diabetes Mellitus, Hyperlipemia and Atherosclerosis - Acta med. scand.177 465, 1965.
Stern L., Shapiro B.: A Rapid and Simple Method for the Determination of Esterified Fatty Acids and for Total Fatty Acids in Blood - J. clin. Path.6 158, 1953.
Strang J. M.: Obesity. In:Duncan G. G.: Disease of Metabolism - W. S. Saunders Co., Philadelphia 1964, pag. 693.
Thannhauser S. J.: Lipidosis - Grune & Stratton, New York 1958, pag. 275.
Tiengo A., Enzi G., Avogaro P., Crepaldi G.: Frequenza e significato di un difetto di attività della lipasi lipoproteica nell'iperlipemia essenziale - Acta med. Patav.25 213, 1965.
Tiez A., Shapiro B.: The Synthesis of Glycerides in Liver Homogenates- Biochim. Biophys. Acta19 374, 1956.
Van Handel E., Zilversmith D. B.: Micromethod for the Direct Determination of Serum Triglycerides - J. Lab. clin. Med.50 152, 1957.
Waddel W., Geyer R. P., Hurley N., Stare F. J.: Abnormal Carbohydrate Metabolism in Patients with Hypercholesterolemia and Hyperlipemia - Metabolism7 707, 1958.
Yalow R. S., Berson S. A.: Immuno-Assay of Endogenous Plasma Insulin in Man - J. clin. Invest.39 1157, 1960.
Zilversmith D. B., Davis A. K.: Microdetermination of Plasma Phospholipids by Thrichloracetic Acid Precipitation - J. Lab. clin. Med.35 155, 1950.
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Avogaro, P., Crepaldi, G., Enzi, G. et al. Associazione di iperlipemia, diabete mellito e obesita' di medio grado. Acta diabet. lat 4, 572–590 (1967). https://doi.org/10.1007/BF01544100
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DOI: https://doi.org/10.1007/BF01544100