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Association of lipid accumulation product with type 2 diabetes mellitus, hypertension, and mortality: a systematic review and meta-analysis

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Abstract

Purpose

Novel anthropometric measures are simple, applicable, and inexpensive tools for cardiovascular risk assessment. This study evaluates the association of lipid accumulation product (LAP) with hypertension, type 2 diabetes mellitus (T2DM), and all-cause mortality, and compares it with other anthropometric measures.

Methods

PubMed, Web of Science, EMBASE, and Scopus were systematically searched for articles published until May 15, 2021. We included all the studies that had measured LAP predictability for T2DM, all-cause mortality, and hypertension with no limitation in comorbidities and follow-up duration. We assessed the predictability measures of LAP for the aforementioned outcomes. We also performed a meta-analysis on four articles on mortality using an inverse variance method by the “meta” package in R software.

Results

Twenty-nine studies were included in the review after applying the eligibility criteria. The hazard ratio for all-cause mortality per one standard deviation increment of LAP was 1.24 (95% confidence interval [CI]: 1.00–1.53; P = 0.0463) in females, and 1.07 (95% CI: 0.74–1.57; P = 0.709) in males. All included studies found a direct association between LAP with T2DM and hypertension. However, studies used different cut-off points for LAP. Most studies found that LAP was superior in predicting T2DM and hypertension compared to conventional indices, e.g., body mass index and waist circumference. We found that LAP may have higher prognostic significance in females compared to males.

Conclusion

LAP is an inexpensive method to evaluate the risk of all-cause mortality, T2DM, and hypertension, and could outperform conventional anthropometric indices in this regard.

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Data availability

All data generated or analyzed during this study are included in this published article and its supplementary information files.

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Authors and Affiliations

  1. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Shaghayegh Khanmohammadi

  2. Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran

    Shaghayegh Khanmohammadi, Hamed Tavolinejad, Arya Aminorroaya & Ali Vasheghani-Farahani

  3. Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Shaghayegh Khanmohammadi, Hamed Tavolinejad & Arya Aminorroaya

  4. Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran

    Yasaman Rezaie

  5. Cardiac Primary Prevention Research Center (CPPRC), Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran

    Haleh Ashraf & Ali Vasheghani-Farahani

  6. Research Development Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Haleh Ashraf

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  1. Shaghayegh Khanmohammadi
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  3. Arya Aminorroaya
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  4. Yasaman Rezaie
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  6. Ali Vasheghani-Farahani
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Contributions

SK was responsible for designing the review protocol, screening eligible studies, extracting data, and writing the primary draft. HT was responsible for designing the review protocol, writing the review protocol, screening the eligible studies, extracting data, and writing the draft. AA was responsible for designing the review protocol, conducting meta-analysis, interpreting results, and writing the draft. YR was responsible for conducting meta-analysis, interpreting results, and writing the draft. HA contributed to designing the review protocol and revising the draft. AV was responsible for designing the review protocol, conceptualization, revising the draft and providing feedback on the review. All the authors approved the final version of the manuscript.

Corresponding author

Correspondence to Ali Vasheghani-Farahani.

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Khanmohammadi, S., Tavolinejad, H., Aminorroaya, A. et al. Association of lipid accumulation product with type 2 diabetes mellitus, hypertension, and mortality: a systematic review and meta-analysis. J Diabetes Metab Disord 21, 1943–1973 (2022). https://doi.org/10.1007/s40200-022-01114-z

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