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Impact of n-3 Docosapentaenoic Acid Supplementation on Fatty Acid Composition in Rat Differs Depending upon Tissues and Is Influenced by the Presence of Dairy Lipids in the Diet

Cite this: J. Agric. Food Chem. 2018, 66, 38, 9976–9988
Publication Date (Web):July 29, 2018
https://doi.org/10.1021/acs.jafc.8b03069
Copyright © 2018 American Chemical Society
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    The n-3 docosapentaenoic acid (n-3 DPA) could be a novel source of n-3 long-chain polyunsaturated fatty acids (LCPUFA) with beneficial physiological effects. Following the supplementation of 0.5% purified n-3 DPA for 3 weeks from weaning, the n-3 DPA content increased in one-half of the 18 studied tissues (from +50% to +110%, p < 0.05) and mostly affected the spleen, lung, heart, liver, and bone marrow. The n-3 DPA was slightly converted into DHA (+20% in affected tissues, p < 0.05) and mostly retroconverted into EPA (35–46% of n-3 DPA intake in liver and kidney) showing an increased content of these LCPUFA in specific tissues. The partial incorporation of dairy lipids in the diet for 6 weeks increased overall n-3 PUFA status and brain DHA status. Furthermore, the n-3 DPA supplementation and dairy lipids had an additive effect on the increase of n-3 PUFA tissue contents. Moreover, n-3 DPA supplementation decreased plasma cholesterol.

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.jafc.8b03069.

    • Supporting Information A, diets and animals; Figure S1, purification of n-3 DPA by liquid chromatography; Figure S2, rats cumulated body weight gain (A) and total weight gain (B); Table S1, organs weight at the end of the experimentation; Supporting Information B, fatty acid composition of tissues of experiment 1; Table S1, liver, red blood cells, and plasma total lipid fatty acid composition; Table S2, gut, stomach, and heart fatty acid composition of total lipids; Table S3, kidney, brain, and retina fatty acid composition of total lipids; Table S4, spleen, lung, and bone marrow fatty acid composition of total lipids; Table S5, pancreas, epididymal adipose tissue (TAE), and skin fatty acid composition of total lipids; Table S6, subcutaneous adipose tissue (SCAT), muscle, and testis fatty acid composition of total lipids; Supporting Information C, fatty acid composition of tissues of experiment 2; Table S1, liver fatty acids composition of total lipids; Table S2, heart fatty acids composition of total lipids; Table S3, lung fatty acids composition of total lipids; Table S4, spleen fatty acids composition of total lipids; Table S5, red blood cells fatty acids composition of total lipids; Table S6, brain fatty acids composition of phospholipids; Supporting Information D, loadings plot of Figure 3; Figure S1, loadings plot of Figure 3A; Figure S2, loadings plot of Figure 3B (PDF)

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    Cited By

    This article is cited by 10 publications.

    1. Nickpreet Singh, Erik Dove, Deepak L. Bhatt. Omega-3 Fatty Acids. 2024, 169-183.e3. https://doi.org/10.1016/B978-0-323-88286-6.00019-4
    2. Satoshi Hirako, Takahiro Hirabayashi, Junko Shibato, Ai Kimura, Michio Yamashita, Yuzuru Iizuka, Nobuhiro Wada, Naoko Kaibara, Fumiko Takenoya, Seiji Shioda. Docosapentaenoic acid-rich oil lowers plasma glucose and lipids in a mouse model of diabetes and mild obesity. Nutrition Research 2023, 118 , 128-136. https://doi.org/10.1016/j.nutres.2023.08.004
    3. Birgitta Strandvik, Abdul Rashid Qureshi, Johanna Painer, Carolina Backman-Johansson, Martin Engvall, Ole Fröbert, Jonas Kindberg, Peter Stenvinkel, Sylvain Giroud, . Elevated plasma phospholipid n-3 docosapentaenoic acid concentrations during hibernation. PLOS ONE 2023, 18 (6) , e0285782. https://doi.org/10.1371/journal.pone.0285782
    4. Aneta Brodziak, Joanna Wajs, Maria Zuba-Ciszewska, Jolanta Król, Magdalena Stobiecka, Anna Jańczuk. Organic versus Conventional Raw Cow Milk as Material for Processing. Animals 2021, 11 (10) , 2760. https://doi.org/10.3390/ani11102760
    5. Hongyan Mu, Xiaodan Li, Qingzhe Jin, Qingjie Sun. Preparation of highly purified ω-3 docosapentaenoic acid from seal oil via urea complexation combined with preparative high performance liquid chromatography. Separation Science and Technology 2021, 56 (10) , 1769-1778. https://doi.org/10.1080/01496395.2020.1794895
    6. Etienne Guillocheau, Gaëtan Drouin, Daniel Catheline, Clément Orione, Philippe Legrand, Vincent Rioux. Chemical Synthesis and Isolation of Trans ‐Palmitoleic Acid ( Trans ‐C16:1 n‐7) Suitable for Nutritional Studies. European Journal of Lipid Science and Technology 2020, 122 (6) https://doi.org/10.1002/ejlt.201900409
    7. Anders K. Nilsson, Carlos Jiménez, Angela Wulff. Nutraceutical Fatty Acid Production in Marine Microalgae and Cyanobacteria. 2020, 23-76. https://doi.org/10.1002/9781119631729.ch2
    8. Zwol, Rimbert, Kuivenhoven. The Future of Lipid-lowering Therapy. Journal of Clinical Medicine 2019, 8 (7) , 1085. https://doi.org/10.3390/jcm8071085
    9. Gaetan Drouin, Vincent Rioux, Philippe Legrand. The n-3 docosapentaenoic acid (DPA): A new player in the n-3 long chain polyunsaturated fatty acid family. Biochimie 2019, 159 , 36-48. https://doi.org/10.1016/j.biochi.2019.01.022
    10. Gaetan Drouin, Daniel Catheline, Etienne Guillocheau, Pierre Gueret, Charlotte Baudry, Pascale Le Ruyet, Vincent Rioux, Philippe Legrand. Comparative effects of dietary n-3 docosapentaenoic acid (DPA), DHA and EPA on plasma lipid parameters, oxidative status and fatty acid tissue composition. The Journal of Nutritional Biochemistry 2019, 63 , 186-196. https://doi.org/10.1016/j.jnutbio.2018.09.029
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