Clinical Endocrinology

Volume 82, Issue 1 p. 147-154

Original Article

Association between habitual physical activity and brown adipose tissue activity in individuals undergoing PET-CT scan

Petros C. Dinas,

Petros C. Dinas

FAME Laboratory, Department of Exercise Science, University of Thessaly, Trikala, Greece

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Alexandra Nikaki,

Alexandra Nikaki

Nuclear Medicine Department and Positron Emission Tomography/Computed Tomography Department, “DTCA HYGEIA” Hospital, Athens, Greece

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Athanasios Z. Jamurtas,

Athanasios Z. Jamurtas

School of Physical Education and Exercise Science, University of Thessaly, Trikala, Greece

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Vassilios Prassopoulos,

Vassilios Prassopoulos

Nuclear Medicine Department and Positron Emission Tomography/Computed Tomography Department, “DTCA HYGEIA” Hospital, Athens, Greece

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Roxani Efthymiadou,

Roxani Efthymiadou

Nuclear Medicine Department and Positron Emission Tomography/Computed Tomography Department, “DTCA HYGEIA” Hospital, Athens, Greece

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Yiannis Koutedakis,

Yiannis Koutedakis

School of Physical Education and Exercise Science, University of Thessaly, Trikala, Greece

Faculty of Education, Health and Wellbeing, University of Wolverhampton, Wolverhampton, UK

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Panagiotis Georgoulias,

Panagiotis Georgoulias

Nuclear Medicine Laboratory, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece

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Andreas D. Flouris,

Corresponding Author

Andreas D. Flouris

FAME Laboratory, Department of Exercise Science, University of Thessaly, Trikala, Greece

Correspondence: Andreas D. Flouris, FAME Laboratory, School of Physical Education and Exercise Science, University of Thessaly, Karies, Trikala, 42100, Greece. Tel.: +302431500601, Fax: +302431063191; E-mail: [email protected]Search for more papers by this author

Petros C. Dinas,

Petros C. Dinas

FAME Laboratory, Department of Exercise Science, University of Thessaly, Trikala, Greece

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Alexandra Nikaki,

Alexandra Nikaki

Nuclear Medicine Department and Positron Emission Tomography/Computed Tomography Department, “DTCA HYGEIA” Hospital, Athens, Greece

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Athanasios Z. Jamurtas,

Athanasios Z. Jamurtas

School of Physical Education and Exercise Science, University of Thessaly, Trikala, Greece

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Vassilios Prassopoulos,

Vassilios Prassopoulos

Nuclear Medicine Department and Positron Emission Tomography/Computed Tomography Department, “DTCA HYGEIA” Hospital, Athens, Greece

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Roxani Efthymiadou,

Roxani Efthymiadou

Nuclear Medicine Department and Positron Emission Tomography/Computed Tomography Department, “DTCA HYGEIA” Hospital, Athens, Greece

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Yiannis Koutedakis,

Yiannis Koutedakis

School of Physical Education and Exercise Science, University of Thessaly, Trikala, Greece

Faculty of Education, Health and Wellbeing, University of Wolverhampton, Wolverhampton, UK

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Panagiotis Georgoulias,

Panagiotis Georgoulias

Nuclear Medicine Laboratory, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece

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Andreas D. Flouris,

Corresponding Author

Andreas D. Flouris

FAME Laboratory, Department of Exercise Science, University of Thessaly, Trikala, Greece

First published: 26 September 2014

https://doi.org/10.1111/cen.12620

Citations: 41

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Summary

Objective

Augmented brown adipose tissue (BAT) mass and activity lead to higher basic metabolic rate which is beneficial against obesity. Our aim was to investigate whether habitual (i.e. usual weekly participation) physical activity is linked with BAT activity and mass in humans, in a group of patients undergoing ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) scanning.

Design

Cross-sectional study.

Patients

Forty patients with cancer [26 male; 14 female; age 52·7 ± 17·5; body mass index (BMI) 26·4 ± 4·5].

Measurements

Patients completed the ‘usual week’ form of the International Physical Activity Questionnaire and underwent assessment of BAT activity/mass via ¹⁸F-fluorodeoxyglucose PET/CT.

Results

We detected a significant association between habitual physical activity (METs-minute/week) and BAT activity [normalized by body weight (BW) (τ = 0·28, P = 0·02), body surface area (BSA) (τ = 0·29, P = 0·02) and lean body mass (LBM) (τ = 0·38, P = 0·002)]. We also found a significant negative relationship between BMI and BAT activity [normalized by BW (τ = −0·30, P = 0·006), BSA (τ = −0·31, P = 0·004) and LBM (τ = −0·45, P = 0·001)] as well as a significant negative relationship between age and BAT activity [normalized by LBM (τ = −0·28, P = 0·01)]. The results also indicate significant differences between low/moderate/high levels of habitual physical activity and BAT activity (P < 0·05). Moreover, BAT activity was different across the BMI categories (normal/overweight/obese) in both sexes (P < 0·05). Finally, BAT activity was greater in women than in men (P < 0·05).

Conclusions

Increased participation in habitual physical activity is associated with higher BAT activity. Moreover, individuals with normal BMI demonstrate higher BAT activity compared to overweight and obese individuals. Finally, age is inversely linked with BAT activity, while women demonstrate higher BAT activity than men.

Supporting Information

Filename	Description
cen12620-sup-0001-FigS1.tifimage/tif, 129 KB	Figure S1. A scatter diagram of the physical activity (in METs-minute/week) and BAT activity (normalized by LBM) that were used to detect outliers.
cen12620-sup-0002-FigS2.tifimage/tif, 291.2 KB	Figure S2. Correlation between habitual physical activity (METs-minute/week) and brown adipose tissue activity normalized by lean body mass.
cen12620-sup-0003-FigS3.tifimage/tif, 980.6 KB	Figure S3. Correlations between body mass index and brown adipose tissue activity normalized by body weight (A), body surface area (B) and lean body mass (C).
cen12620-sup-0004-FigS4.tifimage/tif, 239.9 KB	Figure S4. Results from post hoc Mann–Whitney U tests for brown adipose tissue activity normalized by body weight, body surface area and lean body mass with respect to habitual physical activity (A), body mass index categories (B) and sex (C).
cen12620-sup-0005-FigS5.tifimage/tif, 395.8 KB	Figure S5. Scatterplots illustrating the lack of association between environmental temperature and either BAT activity (top graph), and BAT mass (bottom graph).
cen12620-sup-0006-DataS1.docxWord document, 33.8 KB	Data S1. Purpose and results.

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

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Citing Literature

Volume82, Issue1

January 2015

Pages 147-154

Association between habitual physical activity and brown adipose tissue activity in individuals undergoing PET-CT scan

Summary

Objective

Design

Patients

Measurements

Results

Conclusions

Supporting Information

References

Citing Literature

References

Information

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Association between habitual physical activity and brown adipose tissue activity in individuals undergoing PET-CT scan

Summary

Objective

Design

Patients

Measurements

Results

Conclusions

Supporting Information

References

Citing Literature

References

Related

Information