8K6Z
|
NMR structure of human leptin |
Descriptor: |
Leptin |
Authors: |
Fan, X, Qin, R, Yuan, W, Fan, J, Huang, W, Lin, Z. |
Deposit date: |
2023-07-26 |
Release date: |
2024-02-07 |
Method: |
SOLUTION NMR |
Cite: |
The solution structure of human leptin reveals a conformational plasticity important for receptor recognition.
Structure, 32, 2024
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1AX8
|
Human obesity protein, leptin |
Descriptor: |
OBESITY PROTEIN |
Authors: |
Zhang, F, Beals, J.M, Briggs, S.L, Clawson, D.K, Wery, J.-P, Schevitz, R.W. |
Deposit date: |
1997-10-31 |
Release date: |
1998-11-25 |
Last modified: |
2012-05-09 |
Method: |
X-RAY DIFFRACTION (2.4 Å) |
Cite: |
Crystal structure of the obese protein leptin-E100.
Nature, 387, 1997
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7Z3R
|
Crystal structure of the mouse leptin:LepR-IgCRH2 complex to 2.95 A resolution. |
Descriptor: |
2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin, Leptin receptor |
Authors: |
Verstraete, K, Verschueren, K, Savvides, S.N, Tsirigotaki, A. |
Deposit date: |
2022-03-02 |
Release date: |
2023-03-22 |
Last modified: |
2024-02-07 |
Method: |
X-RAY DIFFRACTION (2.951 Å) |
Cite: |
Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
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7Z3P
|
Crystal structure of the mouse leptin:LepR-CRH2 encounter complex to 1.95 A resolution. |
Descriptor: |
CALCIUM ION, DI(HYDROXYETHYL)ETHER, Leptin, ... |
Authors: |
Tsirigotaki, A, Verschueren, K, Savvides, S.N, Verstraete, K. |
Deposit date: |
2022-03-02 |
Release date: |
2023-03-22 |
Last modified: |
2024-02-07 |
Method: |
X-RAY DIFFRACTION (1.943 Å) |
Cite: |
Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
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7Z3Q
|
Crystal structure of the human leptin:LepR-CRH2 encounter complex to 3.6 A resolution. |
Descriptor: |
Leptin, Leptin receptor |
Authors: |
Verstraete, K, Verschueren, K, Alexandra, T, Savvides, S.N. |
Deposit date: |
2022-03-02 |
Release date: |
2023-03-22 |
Last modified: |
2024-02-07 |
Method: |
X-RAY DIFFRACTION (3.617 Å) |
Cite: |
Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
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8DHA
|
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8DH8
|
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8DH9
|
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8AVO
|
Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (open 3:3 model). |
Descriptor: |
Leptin, Leptin receptor |
Authors: |
Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. |
Deposit date: |
2022-08-26 |
Release date: |
2023-04-05 |
Last modified: |
2023-04-26 |
Method: |
ELECTRON MICROSCOPY (6.84 Å) |
Cite: |
Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
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8AVD
|
Cryo-EM structure for a 3:3 complex between mouse leptin and the mouse LEP-R ectodomain (local refinement) |
Descriptor: |
Leptin, Leptin receptor, NICKEL (II) ION |
Authors: |
Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. |
Deposit date: |
2022-08-26 |
Release date: |
2023-04-05 |
Last modified: |
2023-04-26 |
Method: |
ELECTRON MICROSCOPY (4.42 Å) |
Cite: |
Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
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8AVC
|
Mouse leptin:LEP-R complex cryoEM structure (3:3 model) |
Descriptor: |
Leptin, Leptin receptor, NICKEL (II) ION |
Authors: |
Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. |
Deposit date: |
2022-08-26 |
Release date: |
2023-04-05 |
Last modified: |
2023-04-26 |
Method: |
ELECTRON MICROSCOPY (4.6 Å) |
Cite: |
Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
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8AVF
|
Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (closed 3:3 model) |
Descriptor: |
Leptin, Leptin receptor |
Authors: |
Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. |
Deposit date: |
2022-08-26 |
Release date: |
2023-04-05 |
Last modified: |
2023-04-26 |
Method: |
ELECTRON MICROSCOPY (6.45 Å) |
Cite: |
Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
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8B7Q
|
Cryo-EM structure for the mouse LEPR-CRH2:Leptin:LEPR-Ig complex following symmetry expansion in combination with local refinement |
Descriptor: |
2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin, Leptin receptor |
Authors: |
Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. |
Deposit date: |
2022-09-30 |
Release date: |
2023-04-05 |
Last modified: |
2023-04-26 |
Method: |
ELECTRON MICROSCOPY (4.02 Å) |
Cite: |
Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
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8AVE
|
Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (2:2 model) |
Descriptor: |
Leptin, Leptin receptor |
Authors: |
Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. |
Deposit date: |
2022-08-26 |
Release date: |
2023-04-05 |
Last modified: |
2023-04-26 |
Method: |
ELECTRON MICROSCOPY (5.62 Å) |
Cite: |
Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
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8AVB
|
Cryo-EM structure for mouse leptin in complex with the mouse LEP-R ectodomain (1:2 mLEP:mLEPR model). |
Descriptor: |
Leptin, Leptin receptor |
Authors: |
Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. |
Deposit date: |
2022-08-26 |
Release date: |
2023-04-05 |
Last modified: |
2023-07-26 |
Method: |
ELECTRON MICROSCOPY (4.43 Å) |
Cite: |
Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
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