COX-2 gene expression is correlated with cognitive function in recurrent depressive disorder

Piotr Gałecki; Monika Talarowska; Kinga Bobińska; Janusz Szemraj

doi:10.1016/j.psychres.2013.12.017

COX-2 gene expression is correlated with cognitive function in recurrent depressive disorder

Psychiatry Res. 2014 Feb 28;215(2):488-90. doi: 10.1016/j.psychres.2013.12.017. Epub 2013 Dec 18.

Authors

Piotr Gałecki¹, Monika Talarowska², Kinga Bobińska², Janusz Szemraj³

Affiliations

¹ Department of Adult Psychiatry, Medical University of Lodz, Aleksandrowska 159, 91-229 Lodz, Poland. Electronic address: galeckipiotr@wp.pl.
² Department of Adult Psychiatry, Medical University of Lodz, Aleksandrowska 159, 91-229 Lodz, Poland.
³ Department of Medical Biochemistry, Medical University of Lodz, Lodz, Poland.

PMID: 24388097
DOI: 10.1016/j.psychres.2013.12.017

Abstract

Cyclooxygenase-2(COX-2) may be a key inflammatory enzyme involved in recurrent depressive disorder(rDD). In rDD group, COX-2 expression were higher and significant correlations occurred between COX-2 expression and cognitive functions. In controls there was no significant association between analysed variables. Thus, the COX-2 enzyme may be important for cognitive functioning in rDD.

Keywords: COX-2; Cognition; Depression.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Cognition*
Cyclooxygenase 2 / genetics*
Depressive Disorder / genetics*
Depressive Disorder / psychology
Female
Gene Expression
Humans
Male
Middle Aged
Neuropsychological Tests
Recurrence
Young Adult

Substances

Cyclooxygenase 2
PTGS2 protein, human