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Correspondence| Volume 395, ISSUE 10238, e98, May 30, 2020

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The invisible pandemic

      Many countries (and members of their press media) have marvelled at Sweden's relaxed strategy in the face of the coronavirus disease 2019 (COVID-19) pandemic: schools and most workplaces have remained open, and police officers were not checking one's errands in the street. Severe critics have described it as Sweden sacrificing its (elderly) citizens to quickly reach herd immunity.
      • Henley J
      Swedish PM warned over ‘Russian roulette-style’ Covid-19 strategy.
      The death toll has surpassed our three closest neighbours, Denmark, Norway, and Finland, but the mortality remains lower than in the UK, Spain, and Belgium.
      European Centre for Disease Prevention and Control
      It has become clear that a hard lockdown does not protect old and frail people living in care homes—a population the lockdown was designed to protect.
      BBC
      Coronavirus: Hard to prevent care home deaths, says Chris Whitty.
      Neither does it decrease mortality from COVID-19, which is evident when comparing the UK's experience with that of other European countries.
      PCR testing and some straightforward assumptions indicate that, as of April 29, 2020, more than half a million people in Stockholm county, Sweden, which is about 20–25% of the population, have been infected (Hansson D, Swedish Public Health Agency, personal communication). 98–99% of these people are probably unaware or uncertain of having had the infection; they either had symptoms that were severe, but not severe enough for them to go to a hospital and get tested, or no symptoms at all. Serology testing is now supporting these assumptions.
      • Hedberg K
      Var femte anställd på Danderyds sjukhus har haft smittan.
      These facts have led me to the following conclusions. Everyone will be exposed to severe acute respiratory syndrome coronavirus 2, and most people will become infected. COVID-19 is spreading like wildfire in all countries, but we do not see it—it almost always spreads from younger people with no or weak symptoms to other people who will also have mild symptoms. This is the real pandemic, but it goes on beneath the surface, and is probably at its peak now in many European countries. There is very little we can do to prevent this spread: a lockdown might delay severe cases for a while, but once restrictions are eased, cases will reappear. I expect that when we count the number of deaths from COVID-19 in each country in 1 year from now, the figures will be similar, regardless of measures taken.
      Measures to flatten the curve might have an effect, but a lockdown only pushes the severe cases into the future —it will not prevent them. Admittedly, countries have managed to slow down spread so as not to overburden health-care systems, and, yes, effective drugs that save lives might soon be developed, but this pandemic is swift, and those drugs have to be developed, tested, and marketed quickly. Much hope is put in vaccines, but they will take time, and with the unclear protective immunological response to infection, it is not certain that vaccines will be very effective.
      In summary, COVID-19 is a disease that is highly infectious and spreads rapidly through society. It is often quite symptomless and might pass unnoticed, but it also causes severe disease, and even death, in a proportion of the population, and our most important task is not to stop spread, which is all but futile, but to concentrate on giving the unfortunate victims optimal care.
      I declare no competing interests.

      References

      1. 1.
        • Henley J
        Swedish PM warned over ‘Russian roulette-style’ Covid-19 strategy.
      2. 2.
        • European Centre for Disease Prevention and Control
      3. 3.
        • BBC
        Coronavirus: Hard to prevent care home deaths, says Chris Whitty.
        https://www.bbc.co.uk/news/uk-politics-52386808
        Date: April 22, 2020
        Date accessed: May 1, 2020
      4. 4.
        • Hedberg K
        Var femte anställd på Danderyds sjukhus har haft smittan.

      Linked Articles

      • COVID-19—a very visible pandemic
        • We read the Correspondence by Johan Giesecke,1 a senior consultant to the Swedish Public Health Agency, with considerable concern.
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      • COVID-19—a very visible pandemic
        • Johan Giesecke's1 many claims lead to two concepts. First, that lockdowns were bad, with the Swedish way being the best approach to the pandemic; and second, that everyone in the world would get COVID-19 in a thinly veiled argument that herd immunity was the only way that the virus would be controlled.
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      • COVID-19—a very visible pandemic – Author's reply
        • Let me express thanks to the many colleagues who have provided valuable feedback. I will not address each of these responses individually, but give a collective answer.
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      • COVID-19—a very visible pandemic
        • Johan Giesecke1 referred to the COVID-19 pandemic as an invisible pandemic, estimating that 25% of the Stockholm population was infected by the end of April, 2020, of which 98–99% are unaware of being infected. On April 1, 2020, the media reported that half of the Swedish population might be infected by the end of April, 2020.2 More conservative estimates suggested that at least one-third of the Stockholm population may be seropositive by mid-May, and later that Stockholm might reach herd immunity by mid-June.
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      • COVID-19—a very visible pandemic
        • The COVID-19 pandemic is exacting a confronting and extraordinarily visible toll in lives and livelihoods globally. The last occasion where humanity fought a similar calamitous infectious disease threat was the 1918–19 influenza pandemic. There are many lessons from that pandemic that are still relevant. The first pandemic wave did not grant adequate herd immunity and was followed by one or more subsequent waves, with those waves being more deadly than the initial wave.1 Additionally, stringent public health measures flattened the epidemic curve, preserving hospital capacity and saving many lives.
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      • COVID-19—a very visible pandemic
        • I read with interest the Correspondence by Johan Giesecke.1 Applauding the Swedish model, Giesecke1 posits a “relaxed strategy” or the development of a herd immunity as the way forward in dealing with the COVID-19 pandemic. He recommends that the crucial task is not to stop the spread, “which is all but futile, but to concentrate on giving the unfortunate victims optimal care”. Given the drastic adverse economic consequences of the lockdown globally, the advocacy of herd immunity as a way out appears attractive.
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      • COVID-19—a very visible pandemic
        • Many predictions have been made regarding the slowing spread of COVID-19; it is not my intention to refute the epidemiological position of Johan Giesecke in his Correspondence.1 However, I will respond as a student doctor concerned about the broader implications.
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