Magnesium deficiency induces anxiety and HPA axis dysregulation: Modulation by therapeutic drug treatment
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Highlights
► Robustness and validity of the Mg2+ deficiency model of enhanced anxiety is shown. ► The Mg2+ deficiency model is sensitive to anxiolytic/antidepressant treatments. ► We suggest an inverse relationship between Mg2+ and anxiety. ► An aberrant HPA axis may contribute to the hyper-emotionality of Mg2+ deficiency.
Keywords
Magnesium
Anxiety
Stress axis
Selective serotonin re-uptake inhibitor
Diazepam
Corticotropin releasing hormone
ACTH
Desipramine
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