REVIEW ARTICLE
Adipocytokine correlates of childhood and adolescent mental health: A systematic review
Samantha R. Scott,
Summer N. Millwood,
Erika M. Manczak,
Corresponding Author
Samantha R. Scott
Biology, Environments, and Mood Studies Lab, Department of Psychology, University of Denver, Denver, Colorado, USA
Correspondence
Samantha Scott, Department of Psychology, University of Denver, 2155 S. Race Street, Denver, CO 80210, USA.
Email: [email protected]
Search for more papers by this authorSummer N. Millwood
Biology, Environments, and Mood Studies Lab, Department of Psychology, University of Denver, Denver, Colorado, USA
Search for more papers by this authorErika M. Manczak
Biology, Environments, and Mood Studies Lab, Department of Psychology, University of Denver, Denver, Colorado, USA
Search for more papers by this author
Samantha R. Scott,
Summer N. Millwood,
Erika M. Manczak,
Corresponding Author
Samantha R. Scott
Biology, Environments, and Mood Studies Lab, Department of Psychology, University of Denver, Denver, Colorado, USA
Correspondence
Samantha Scott, Department of Psychology, University of Denver, 2155 S. Race Street, Denver, CO 80210, USA.
Email: [email protected]
Search for more papers by this authorSummer N. Millwood
Biology, Environments, and Mood Studies Lab, Department of Psychology, University of Denver, Denver, Colorado, USA
Search for more papers by this authorErika M. Manczak
Biology, Environments, and Mood Studies Lab, Department of Psychology, University of Denver, Denver, Colorado, USA
Search for more papers by this author
First published: 13 March 2023
Abstract
The objective of this systematic review was to determine the current state of the literature regarding how adipocytokines associate with mental health symptoms/disorders in youth. Findings summarized in this review suggested that in neurodevelopmental disorders, higher levels of leptin, ghrelin, resistin, and visfatin as well as lower levels of adiponectin, retinol-binding protein 4, and progranulin predicted increased risk for or were conflated with autism spectrum disorder. Adipocytokine correlates of attention-deficit hyperactivity disorder and related symptoms included higher apelin, higher leptin-to-adiponectin ratio, and lower adiponectin. Evidence from studies examining anxiety symptoms evinced mixed results regarding leptin, and one study suggested higher levels of ghrelin. Depressive symptoms correlated with higher leptin and ghrelin. Research examining posttraumatic stress symptoms found higher levels of ghrelin. In research examining broadband symptoms, conflicting results emerged for associations between internalizing symptoms (i.e., symptoms of emotional stress) and leptin in youth. Low levels of adiponectin and high levels of leptin predicted externalizing symptoms. Total symptom difficulties were associated with a higher leptin-to-adiponectin ratio. Our findings suggest that adipocytokines may be an important set of biomarkers to consider as underlying mechanisms contributing to developmental psychopathology.
CONFLICT OF INTEREST STATEMENT
The authors declare no conflict of interest.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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