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Assisted Reproductive Technology (ART) Data

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National Data

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Clinic Services & Profile
Patient & Cycle Characteristics
Success Rates: Patients Using Own Eggs
Success Rates: Patients Using Donor Eggs
Clinic Data Summary

This tab shows what percentage of all reporting fertility clinics in the U.S. performed certain services, held membership with SART, or used an accredited embryo laboratory in 2021. This tab also displays a national summary of all ART cycles started in 2021 and the outcomes of these cycles.

Clinic Profile
National Services & Profile
National Service & Profile
Donor egg services	88%
Donated embryo services	61%
Embryo cryopreservation services	100%
Egg cryopreservation services	99%
Gestational carrier services	90%
SART member	80%
Verified lab accreditation
Yes	89%
No	9%
Pending	2%

Clinic Summary
2021 National Summary	Number
Total cycles	413,776
Fertility preservation cycles	36,072
Pregnancies	112,088
Deliveries	91,906
Total infants born	97,128

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Patient and cycle characteristics summarize the types of ART services performed and the kinds of patients who received ART procedures. Please note that patient characteristics are presented per cycle rather than per patient. As a result, patients who had more than one ART cycle within the reporting year are represented more than once.Show full description

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The ages of patients who used ART are categorized into four groups: patients younger than age 35, aged 35-37, aged 38-40, and older than age 40. Because a woman's fertility declines with age, ART data are reported separately by age group. You may wish to find a clinic that commonly sees patients your age. The denominator for this measure is the total number of ART cycles. The numerator is the number of cycles that had patients in each age group.Show full description

What were the ages of patients who used ART?

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National information based on 413,776 ART cycles.

Success rates for patients using their own eggs are shown per intended retrieval, per actual retrieval, and per transfer. These success rates are reported as cumulative success rates, which take into account transfers that occur within 1 year after an egg retrieval. Since ART success depends on whether patients are using ART for the first time or had prior ART cycles, the drop-down menu allows users to examine success rates for all "Patients using their own eggs" or for "Patients with no prior ART using their own eggs." Show full description

Patient type
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Displayed below are the cumulative percentages of cycles started in the previous year with the intent to retrieve eggs that resulted in a live-birth delivery. Not all cycles started with the intent to retrieve eggs result in actual egg retrieval; some cycles may be canceled before the egg retrieval is performed for many reasons. Therefore, the number of intended retrievals may be higher than the number of actual retrievals. A live-birth delivery is the delivery of one or more infants with at least one born alive. The denominator for this measure includes the number of intended retrievals. The numerator includes the number of live-birth deliveries that have resulted from the intended retrievals and associated transfers within 12 months of cycle start. For example, if a clinic started 60 intended egg retrievals, and these resulted in 30 live-birth deliveries, the average live-birth delivery rate for intended retrievals would be 30 (live-birth deliveries) ÷ 60 (intended retrievals) = 0.5, or 50.0% of intended retrievals resulting in a live-birth delivery. Show full description

Diagnosis

No filterF009

Male factorF006

EndometriosisF005

Tubal factorF001

Ovulatory dysfunctionF003

Uterine factorF002

Diminished ovarian reserveF004

Recurrent pregnancy lossF007

Unexplained factorF008

Patients using donor eggs/embryos

What percentage of intended egg retrievals resulted in live-birth deliveries?

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Patients using their own eggs

What percentage of intended egg retrievals resulted in live-birth deliveries?

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Patients with no prior ART using their own eggs

What percentage of intended egg retrievals resulted in live-birth deliveries?

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Success rates for ART cycles that involve the transfer of embryos created from donor eggs or donated embryos are shown. Intended female parents who have premature ovarian failure (early menopause), whose ovaries have been removed, or who have a genetic concern about using their own eggs may consider using eggs that are donated by a woman without these conditions. Embryos may also be donated by patients who previously used ART. Embryos may be transferred to the intended parent or to a gestational carrier.

Success rates presented in this section are noncumulative. They are based on donor cycles started in 2021 that had embryo transfers, regardless of when the donor eggs were retrieved. This section also includes cycles in which intended parents transferred donated embryos in 2021. Success rates in this section are not presented by patient age group because previous data show that an intended parent's age does not substantially affect success when using donor eggs or donated embryos. The success rates are presented by types of eggs and embryos used in the transfer.Show full description

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Displayed below are the percentages of donor transfers in 2021 that resulted in a live-birth delivery. A live-birth delivery is the delivery of one or more infants with at least one born alive. The denominator for this measure includes the number of transfers in which at least one embryo created from a donor egg or donated embryo was used. The numerator includes the number of live-birth deliveries that resulted from the transfer of these embryos. For example, if 20 donor transfers resulted in 10 live-birth deliveries, the average success rate per transfer would be 10 (live-birth deliveries) ÷ 20 (transfers) = 0.5, or 50.0% of donor egg or donated embryo transfers resulting in a live-birth delivery.Show full description

Diagnosis

No filterF009

Male factorF006

EndometriosisF005

Tubal factorF001

Ovulatory dysfunctionF003

Uterine factorF002

Diminished ovarian reserveF004

Recurrent pregnancy lossF007

Unexplained factorF008

Patients using donor eggs/embryos

What percentage of embryo transfers resulted in live-birth deliveries?

Filter: No filter

Select another filter

The Clinic Data Summary provides a full snapshot of clinic services and profile, patient characteristics, and ART success rates.

DISCLAIMER: Patient medical characteristics, such as age, diagnosis, and ovarian reserve, affect the success of ART treatment. Comparison of success rates across clinics may not be meaningful due to differences in patient populations and ART treatment methods. The success rates displayed here do not reflect any one patient's chance of success. Patients should consult with a doctor to understand their chance of success based on their own characteristics.

Cumulative ART Success Rates for Intended Retrievals Among Patients Using Their Own Eggs ^a,b,c Number of reporting clinics: 453

All patients (with or without prior ART cycles)	<35	35-37	38-40	>40
Number of intended retrievals	52,165	33,021	31,834	27,753
Percentage of intended retrievals resulting in live-birth deliveries	50.7%	36.3%	23.3%	7.9%
Percentage of intended retrievals resulting in singleton live-birth deliveries	47.0%	34.0%	22.0%	7.5%
Number of retrievals	49,182	30,139	28,140	23,202
Percentage of retrievals resulting in live-birth deliveries	53.7%	39.7%	26.4%	9.4%
Percentage of retrievals resulting in singleton live-birth deliveries	49.8%	37.3%	24.9%	9.0%
Number of transfers	53,842	26,699	18,431	8,973
Percentage of transfers resulting in live-birth deliveries	49.1%	44.8%	40.2%	24.4%
Percentage of transfers resulting in singleton live-birth deliveries	45.5%	42.1%	38.0%	23.3%
Average number of intended retrievals per live-birth delivery	2.0	2.8	4.3	12.7

New patients (with no prior ART cycles)	<35	35-37	38-40	>40
Percentage of new patients having live-birth deliveries after 1 intended retrieval	54.6%	40.1%	25.8%	8.5%
Percentage of new patients having live-birth deliveries after 1 or 2 intended retrievals	60.5%	47.7%	32.6%	11.7%
Percentage of new patients having live-birth deliveries after all intended retrievals	61.5%	49.5%	35.2%	13.3%
Average number of intended retrievals per new patient	1.2	1.3	1.4	1.5
Average number of transfers per intended retrieval	1.1	0.8	0.6	0.3

Noncumulative ART Success Rates for Transfers Among Patients Using Eggs or Embryos from a Donor or Donated Embryos ^a,b,c,d

	Fresh Embryos Fresh Eggs	Fresh Embryos Frozen Eggs	Frozen Embryos	Donated Embryos
Number of transfers	1,113	2,859	17,885	3,118
Percentage of transfers resulting in live-birth deliveries	53.5%	45.8%	46.3%	42.3%
Percentage of transfers resulting in singleton live-birth deliveries	49.3%	43.0%	43.6%	38.1%

Characteristics of ART Cycles ^a,b

	<35	35-37	38-40	>40	Total
Total number of cycles	149,687	96,990	85,658	81,441	413,776
Percentage of intended egg retrieval cycles without any eggs retrieved ^e	4.7%	6.9%	9.9%	14.8%	8.4%
Percentage of cycles discontinued after retrieval and before transfer or banking ^f	8.5%	9.3%	12.1%	17.4%	11.2%
Percentage of cycles for fertility perservation	9.1%	11.0%	8.9%	5.1%	8.7%
Percentage of transfers using a gestational carrier	2.9%	3.5%	4.1%	9.0%	4.4%
Percentage of transfers using frozen embryos	84.0%	86.1%	84.6%	79.8%	83.8%
Percentage of transfers of at least 1 embryo with intracytoplasmic sperm injection	81.9%	79.7%	77.5%	67.3%	77.9%
Percentage of transfers of at least 1 embryo with preimplantation genetic testing	47.7%	57.4%	59.5%	48.1%	52.4%

Clinic Services & Profile

Donor egg services	88%
Donated embryo services	61%
Embryo cryopreservation services	100%
Egg cryopreservation services	99%
Gestational carrier services	90%
SART member	80%
Verified lab accreditation - Yes	89%
Verified lab accreditation - No	9%
Verified lab accreditation - Pending	2%

Reason for Using ART ^a,b,g

Male factor	28%
Endometriosis	6%
Tubal factor	11%
Ovulatory dysfunction	14%
Uterine factor	6%
Preimplantation genetic testing	17%
Gestational carrier	1%
Diminished ovarian reserve	27%
Egg or embryo banking	41%
Recurrent pregnancy loss	6%
Other factor, infertility	24%
Other factor, non-infertility	6%
Unexplained factor	11%

ART = assisted reproductive technology; SART = Society for Assisted Reproductive Technology.
^a Numbers and percentages exclude 7 research cycles that were evaluating new procedures.
^b Fractions are used when the denominator is less than 20. ^*Reported sample sizes of 1 through 4 were suppressed due to small sample size. Data that can be used to
   derive suppressed cell values are also suppressed.
^c A live birth is defined as the delivery of one or more infants with at least one born alive. Multiple-birth deliveries (such as twins)
with at least one live-born infant are counted as one live birth. Success rates for cycles using a patient's own eggs are calculated by using all cycles started in 2020 with   the intent to retrieve a patient's eggs and all transfers of embryos created from these eggs started within 12 months of the start of the retrieval cycle. Success rates   for cycles using a donor's eggs or donated embryos are calculated by using all transfers started in 2021.
^d Patients of all ages are combined because previous data show that a patient's age does not substantially affect success when using a donor's eggs or donated
   embryos.
^e Includes cycles in which no eggs were retrieved among all cycles in which egg retrieval was intended.
^f Includes cycles in which no eggs or embryos were transferred or frozen among all cycles in which eggs were retrieved and all frozen cycles.
^g Reasons may add to more than 100% because more than one diagnosis can be reported for each ART cycle.

Description of Clinic Services & Profile

Service	Description
Donor egg services	A clinic may have a donor egg program for ART in which a donor egg is retrieved from one woman (the donor) and fertilized with either partner or donor sperm, and then the resulting embryo is transferred to the uterus of another woman (the recipient). A "Yes" indicates the clinic provided the service, and a "No" means they did not.
Donated embryo services	A clinic may have a donated embryo program using embryos that were donated by other patients who previously underwent ART treatment and had extra embryos available. A "Yes" indicates the clinic provided the service, and a "No" means they did not.
Embryo cryopreservation services	A clinic may have a program for embryo cryopreservation, or freezing embryos for potential future use. A "Yes" indicates the clinic provided the service, and a "No" means they did not.
Egg cryopreservation services	A clinic may have a program for egg cryopreservation, or freezing eggs for potential future use. A "Yes" indicates the clinic provided the service, and a "No" means they did not.
Gestational carrier services	A clinic may have a gestational carrier program. A gestational carrier or surrogate is a woman who gestates, or carries, an embryo that was formed from the egg of another woman with the expectation of returning the infant to its intended parents. Some states do not permit clinics to offer this service. A "Yes" indicates the clinic provided the service, and a "No" means they did not.
SART member	A clinic may be a member of the Society for Assisted Reproductive Technology (SART) - a professional society composed of clinics and programs that provide ART and an affiliate of the American Society for Reproductive Medicine (ASRM). A "Yes" indicates the clinic was a member of SART at the time of reporting, and a "No" means it was not.
Verified lab accreditation	A clinic laboratory may be accredited by at least one of the specified accrediting organizations: the College of American Pathologists, or The Joint Commission. A "Yes" indicates the clinic had an embryo laboratory accreditation at the time of reporting by at least one of the specified accrediting organizations. A "No" indicates that the embryo laboratory was not accredited by any of these organizations or did not provide proof of accreditation to CDC. A "Pending" means that the clinic submitted an application for accreditation to one or both of the organizations and provided proof of such application to CDC. Please note that effective in 2021, the New York State Tissue Bank is no longer providing accreditation for embryo laboratories.

Description of Clinic Summary

Service	Description
Total cycles	The total number of all ART cycles started, which usually means that a woman began taking medication to stimulate egg production or began monitoring with the intent of having embryos transferred. The total number of ART cycles is calculated as the sum of (1) the number of cycles started with the intent to freeze all resulting eggs or embryos (for example, short term banking or fertility preservation); (2) the number of cycles started with the intent to transfer fresh or frozen eggs retrieved from either the patient or donor; and (3) the number of cycles started with the intent to transfer fresh or frozen embryos created from fresh or frozen eggs retrieved from either the patient or donor.
Fertility preservation cycles	The total number of ART cycles started with the intent of freezing and banking all eggs or embryos for at least 12 months for future use.
Pregnancies	The total number of pregnancies that resulted from ART cycles. Because some pregnancies end in a miscarriage or stillbirth, the number of pregnancies may be higher than the number of deliveries or infants born.
Deliveries	The total number of live-birth deliveries of infants conceived with the help of ART. One delivery could result in one or more infants born.
Total infants born	The total number of infants born who were conceived using ART, including singleton infants and infants born in a multiple-birth delivery (such as twins or triplets).

Diagnosis Description

Diagnosis	Description
No filter
Male factor	Male factor infertility refers to any cause of infertility due to low sperm count or problems with sperm function that makes it difficult for a sperm to fertilize an egg under normal conditions.
Endometriosis	Endometriosis is a medical condition that involves the presence of tissue similar to the uterine lining in abnormal locations. This condition can affect both fertilization of the egg and embryo implantation.
Tubal factor	Tubal factor infertility is a diagnostic category used when the woman’s fallopian tubes are blocked or damaged, making it difficult for the egg to be fertilized or for an embryo to travel to the uterus.
Ovulatory dysfunction	Ovulatory dysfunction is a diagnostic category used when a woman’s ovaries are not producing eggs normally. It includes polycystic ovary syndrome and multiple ovarian cysts.
Uterine factor	Uterine factor infertility is a structural or functional disorder of the uterus that results in reduced fertility.
Diminished ovarian reserve	Diminished ovarian reserve means that the ability of the ovary to produce eggs is reduced. Reasons include congenital, medical, surgical causes, or advanced age.
Recurrent pregnancy loss	Recurrent pregnancy loss is a diagnostic category in which a patient has experienced the spontaneous loss of two or more pregnancies.
Unexplained factor	Unexplained infertility is a diagnostic category used when no cause of infertility is found in either the woman or the man.

Egg/Embryo Type Descriptions

Egg Type	Description
Fresh Embryos Fresh Eggs	This group of ART cycles involves fresh embryos created from fresh donor eggs. The eggs were retrieved from a donor and fertilized during the current cycle. Neither the eggs from a donor nor any resulting embryos were ever frozen prior to transfer.
Fresh Embryos Frozen Eggs	This group of ART cycles involves fresh embryos created from frozen donor eggs. The eggs were retrieved from a donor during a previous cycle and frozen for future use. The eggs were then thawed, fertilized, and transferred in the current year. The eggs from the donor were frozen prior to transfer, but any resulting embryos were not.
Frozen Embryos	This group of ART cycles involves frozen embryos created from fresh or frozen donor eggs. In the case of fresh donor eggs, the eggs were retrieved from a donor during a previous cycle and immediately fertilized, and then the resulting embryos were frozen for future use. In the case of frozen donor eggs, the eggs were retrieved from a donor during a previous cycle, frozen, thawed, and fertilized, and then the resulting embryos were frozen for future use. For both fresh and frozen eggs from donors, the frozen embryos were thawed in the current year for transfer.
Donated Embryos	This group of ART cycles involves donated embryos for transfer in the current year—that is, embryos donated from another patient or couple after their own ART treatment. The embryos can be fresh or frozen.

Descriptions of Reasons

Name	Description
Tubal factor	Tubal factor infertility is a diagnostic category used when the woman’s fallopian tubes are blocked or damaged, making it difficult for the egg to be fertilized or for an embryo to travel to the uterus.
Uterine factor	Uterine factor infertility is a structural or functional disorder of the uterus that results in reduced fertility.
Ovulatory dysfunction	Ovulatory dysfunction is a diagnostic category used when a woman’s ovaries are not producing eggs normally. It includes polycystic ovary syndrome and multiple ovarian cysts.
Diminished ovarian reserve	Diminished ovarian reserve means that the ability of the ovary to produce eggs is reduced. Reasons include congenital, medical, surgical causes, or advanced age.
Endometriosis	Endometriosis is a medical condition that involves the presence of tissue similar to the uterine lining in abnormal locations. This condition can affect both fertilization of the egg and embryo implantation.
Male factor	Male factor infertility refers to any cause of infertility due to low sperm count or problems with sperm function that makes it difficult for a sperm to fertilize an egg under normal conditions.
Egg or embryo banking	Egg or embryo banking cycle. An ART cycle started with the intention of freezing (cryopreserving) all resulting eggs or embryos for potential future use.
Recurrent pregnancy loss	Recurrent pregnancy loss is a diagnostic category in which a patient has experienced the spontaneous loss of two or more pregnancies.
Preimplantation genetic testing	Preimplantation genetic testing (PGT). Diagnostic or screening techniques performed on embryos prior to transfer for detecting specific genetic conditions to reduce the risk of passing inherited diseases to children or screening for an abnormal number of chromosomes, which is of special value for patients with advanced age, recurrent miscarriages, or prior failed in vitro fertilization.
Gestational carrier	Gestational carrier (also called a gestational surrogate). A woman who gestates, or carries, an embryo that was formed from the egg of another woman with the expectation of returning the infant to its intended parents.
Other factor	Other known reasons may be either related to infertility (such as immunological problems, chromosomal abnormalities, cancer chemotherapy, serious illnesses), or not related to infertility, but not unexplained.
Unexplained factor	Unexplained infertility is a diagnostic category used when no cause of infertility is found in either the woman or the man.

Cycle Type

Cycle Types
Cycle Type	Description
Patients using their own eggs	Own ART cycles are those cycles in which a woman's own embryos are transferred to the woman.

• HHS Office on Women's Health	• Society for Assisted Reproductive Technology (SART)	• American Society for Reproductive Medicine (ASRM)
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Assisted Reproductive Technology (ART) Data

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Description of Clinic Services & Profile

Description of Clinic Summary

Diagnosis Description

Egg/Embryo Type Descriptions

Descriptions of Reasons

Cycle Type

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